4-Hexylresorcinol - CAS 136-77-6
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
4-Hexylresorcinol, a phenol derivative, could be commonly used as antioxidant, vermifuge and food additives.
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Pale-yellow viscous liquid (that becomes solid on standing at room temperature) or a peach colored powder. Pungent faintly fatty odor. Sharp astringent taste.
1-(2',4'-Dihydroxyphenyl)hexane;1-(2,4-Dihydroxyphenyl)hexane;1,3-Benzenediol, 4-hexyl-;1,3-Benzenediol,4-Hexyl-1,3-benzenediol;1,3-Dihydroxy-4-Hexylbenzene;1,3-Dihydroxy-4-n-hexylbenzene
DMSO: ≥ 1.8 mg/mL
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
4-Hexylresorcinol could be commonly used as antioxidant, vermifuge and food additives.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Boiling Point:
Melting Point:
1.049 g/cm3
Canonical SMILES:
1.Development and validation of an analytical method for the determination of 4-hexylresorcinol in food.
Kim YH1, Kim JM1, Lee JS1, Gang SR2, Lim HS3, Kim M3, Lee OH4. Food Chem. 2016 Jan 1;190:1086-92. doi: 10.1016/j.foodchem.2015.06.051. Epub 2015 Jun 19.
This study presents a method validation for extraction and quantitative analysis of 4-hexylresorcinol residues in shrimp and crab meat using HPLC-FLD. We were focused on the collaboratively analysis of each shrimp and crab meat samples, and developed LC-MS/MS method for the correct confirmation of the identity of compound. Validation parameters; selectivity, linearity, LOD, LOQ, accuracy, precision, and measurement of uncertainty were attained. The measurement of uncertainty was based on the precision study, data related to the performance of the analytical process and quantification of 4-hexylresorcinol. For HPLC-FLD analysis, the recoveries of 4-hexylresorcinol from spiked samples at levels of 0.2-10.0 ppm ranged from 92.54% to 97.67% with RSDs between 0.07% and 1.88%. According to these results, the method has been proven to be appropriate for extraction and determination of 4-hexylresorcinol, and can be used to maintain the safety of shrimp and crab products containing 4-hexylresorcinol residues.
2.Tyrosinase-Catalyzed Hydroxylation of 4-Hexylresorcinol, an Antibrowning and Depigmenting Agent: A Kinetic Study.
Ortiz-Ruiz CV1, Berna J1, Rodriguez-Lopez JN1, Tomas V1, Garcia-Canovas F1. J Agric Food Chem. 2015 Aug 12;63(31):7032-40. doi: 10.1021/acs.jafc.5b02523. Epub 2015 Jul 29.
4-Hexylresorcinol (HR) is a compound used in the food and cosmetic industries as an antibrowning and lightening agent. Its use is mainly attributed to its inhibitory effect on the enzyme tyrosinase. However, the enzyme hydroxylates HR to an o-diphenol, which it then oxidizes to an o-quinone, which rapidly isomerizes to p-quinone. For tyrosinase to act in this way, the Eox form (oxy-tyrosinase) must be present in the reaction medium, which can be brought about by (a) hydrogen peroxide, (b) ascorbic acid, or (c) catalytic concentrations of o-diphenol and a reductant (NADH) to maintain it constant. This work demonstrates that HR is a substrate of tyrosinase and proposes a mechanism for its action. Its kinetic characterization provides a catalytic constant of 0.85 ± 0.04 s(-1) and a Michaelis constant of 60.31 ± 6.73 μM.
3.Silk fibroin and 4-hexylresorcinol incorporation membrane for guided bone regeneration.
Lee SW1, Kim SG, Song JY, Kweon H, Jo YY, Lee KG, Kang SW, Yang BE. J Craniofac Surg. 2013 Nov;24(6):1927-30. doi: 10.1097/SCS.0b013e3182a3050c.
The objective of this study was to demonstrate that a silk fibroin (SF) and 4-hexylresorcinol (4-HR) incorporation membrane could be used for a guided bone regeneration technique. Fourier transform infrared measurements were obtained to determine change of physical property of SF membrane by 4-HR incorporation. Two peri-implant defects, 3.0 × 5.0 mm (width × length), were prepared on the lateral side of the implant hole in the tibia of New Zealand white rabbits (n = 8). The peri-implant defect was left unfilled in the control group. Silk fibroin + 4-HR membrane was applied to the peri-implant defect in the experimental group. The 8 animals were killed at 8 weeks after implantation. Subsequently, removal torque test and histomorphometric evaluation were done. Fourier transform infrared spectroscopy showed no specific chemical interaction between 4-HR and SF. In the histomorphometric analysis, the mean bone regeneration was 18.3 ± 1.9 mm(2) in the experimental group and 9.
4.Trends in patch-test results and allergen changes in the standard series: a Mayo Clinic 5-year retrospective review (January 1, 2006, to December 31, 2010).
Wentworth AB1, Yiannias JA2, Keeling JH3, Hall MR3, Camilleri MJ4, Drage LA5, Torgerson RR5, Fett DD6, Prakash AV7, Scalf LA8, Allen EM5, Johnson JS2, Singh N2, Nordberg Linehan DL3, Killian JM9, Davis MD10. J Am Acad Dermatol. 2014 Feb;70(2):269-75.e4. doi: 10.1016/j.jaad.2013.09.047. Epub 2013 Nov 20.
BACKGROUND: Patch testing is essential for identification of culprits causing allergic contact dermatitis.
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CAS 136-77-6 4-Hexylresorcinol

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