4-​amino-​1-​(2-​deoxy-​2,​2-​difluoro-​D-​erythro-​pentofuranosyl)​-2(1H)​-​Pyrimidinone - CAS 103882-84-4
Molecular Formula:
C9H11F2N3O4
Molecular Weight:
263.198
COA:
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Description:
An isomer of Gemcitabina. Gemcitabine is a nucleoside analog used to treat various cancers including, non-small cell lung cancer, pancreatic cancer, bladder cancer, and breast cancer.
Purity:
95%
Synonyms:
Gemcitabina
MSDS:
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1.Gemcitabine enhances antitumor efficacy of recombinant lipoimmunogen-based immunotherapy.
Chang LS1, Yan WL2, Chang YW2, Yeh YC2, Chen HW3, Leng CH3, Liu SJ3. Oncoimmunology. 2015 Oct 29;5(3):e1095433. eCollection 2016.
Although immunotherapy is an attractive approach for cancer treatment, increasing evidence has shown that the combination of immunotherapy with other treatment modalities may improve the outcome of advanced malignancy. We combined the anticancer drug gemcitabine (Gem) with recombinant lipoprotein-based immunotherapy (rlipo-E7m/CpG) to treat advanced cancer. Mice bearing huge solid tumors (≧ 12 mm in diameter) or orthotopic cervical cancer were treated with a therapeutic regimen consisting of rlipo-E7m/CpG and Gem. In addition, tumor-infiltrating immune cells were quantified by flow cytometry following the chemotherapy and/or immunotherapy. We observed the eradication of huge tumors following the administration of Gem on days 21, 24, and 27 or following rlipo-E7m/CpG therapy on day 30 post-tumor implantation. The combination therapy substantially reduced the number of immunosuppressive cells (CD11b+Gr-1+, CD11b+F4/80+, and CD4+CD25+FOXP3+) and increased the number of tumor-infiltrating antigen-specific CD8+ T cells compared to Gem or rlipo-E7m/CpG monotherapy.
2.Effect of Chemoradiotherapy vs Chemotherapy on Survival in Patients With Locally Advanced Pancreatic Cancer Controlled After 4 Months of Gemcitabine With or Without Erlotinib: The LAP07 Randomized Clinical Trial.
Hammel P1, Huguet F2, van Laethem JL3, Goldstein D4, Glimelius B5, Artru P6, Borbath I7, Bouché O8, Shannon J9, André T10, Mineur L11, Chibaudel B12, Bonnetain F13, Louvet C14. JAMA. 2016 May 3;315(17):1844-53. doi: 10.1001/jama.2016.4324.
IMPORTANCE: In locally advanced pancreatic cancer, the role of chemoradiotherapy is controversial and the efficacy of erlotinib is unknown.
3.Low dose gemcitabine-loaded lipid nanocapsules target monocytic myeloid-derived suppressor cells and potentiate cancer immunotherapy.
Sasso MS1, Lollo G2, Pitorre M2, Solito S1, Pinton L1, Valpione S3, Bastiat G2, Mandruzzato S4, Bronte V5, Marigo I6, Benoit JP7. Biomaterials. 2016 Apr 22;96:47-62. doi: 10.1016/j.biomaterials.2016.04.010. [Epub ahead of print]
Tumor-induced expansion of myeloid-derived suppressor cells (MDSCs) is known to impair the efficacy of cancer immunotherapy. Among pharmacological approaches for MDSC modulation, chemotherapy with selected drugs has a considerable interest due to the possibility of a rapid translation to the clinic. However, such approach is poorly selective and may be associated with dose-dependent toxicities. In the present study, we showed that lipid nanocapsules (LNCs) loaded with a lauroyl-modified form of gemcitabine (GemC12) efficiently target the monocytic (M - ) MDSC subset. Subcutaneous administration of GemC12-loaded LNCs reduced the percentage of spleen and tumor-infiltrating M-MDSCs in lymphoma and melanoma-bearing mice, with enhanced efficacy when compared to free gemcitabine. Consistently, fluorochrome-labeled LNCs were preferentially uptaken by monocytic cells rather than by other immune cells, in both tumor-bearing mice and human blood samples from healthy donors and melanoma patients.
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CAS 103882-84-4 4-​amino-​1-​(2-​deoxy-​2,​2-​difluoro-​D-​erythro-​pentofuranosyl)​-2(1H)​-​Pyrimidinone

4-​amino-​1-​(2-​deoxy-​2,​2-​difluoro-​
(CAS: 103882-84-4)

An isomer of Gemcitabina. Gemcitabine is a nucleoside analog used to treat various cancers including, non-small cell lung cancer, pancreatic cancer, bladder can...

Chemical Structure

CAS 103882-84-4 4-​amino-​1-​(2-​deoxy-​2,​2-​difluoro-​D-​erythro-​pentofuranosyl)​-2(1H)​-​Pyrimidinone

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