|Description||4,9-Anhydrotetrodotoxin is a derivative of tetrodotoxin, which is a potent neurotoxin and can be isolated from pufferfish. It is also a selective and potent Nav1.6 channel blocker with IC50 value of 7.8 nM. It selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels. It may be a useful compound for treating diseases related to the voltage-gated sodium channel α subunit Nav1.6.|
|Purity||≥98% by HPLC|
|Synonyms||(4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-Epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol; (4β,9β)-4,9-Dideoxy-4,9-epoxy-tetrodotoxin; Anhydro-tetrodotoxin; Anhydroepitetrodotoxin; 4,9-anhydro-TTX|
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