4-(2-aminopropyl)phenol - CAS 103-86-6
Catalog number: 103-86-6
Category: Inhibitor
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Molecular Formula:
C9H13NO
Molecular Weight:
151.21
COA:
Inquire
Targets:
Others
Description:
Hydroxyamphetamine, an active metabolite product of amphetamine, is a prescription drug that could stimulate the sympathetic nervous system and commonly be used to dilate the pupil in eye drops.
Purity:
98%
Appearance:
Powder
Synonyms:
4-(2-Aminopropyl)phenol; Hydroxyamphetamine; Paredrine; Norpholedrine; Oxamphetamine; Hydroxyamfetamine
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Hydroxyamphetamine is a prescription drug that could stimulate the sympathetic nervous system and commonly be used to dilate the pupil in eye drops.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
GIKNHHRFLCDOEU-UHFFFAOYSA-N
InChI:
InChI=1S/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3
Canonical SMILES:
CC(CC1=CC=C(C=C1)O)N
1.The metabolism of p-methoxyamphetamine in dog and monkey. O-demethylation as a major route.
Hubbard JW;Midha KK;Cooper JK Drug Metab Dispos. 1977 Jul-Aug;5(4):329-34.
p-Hydroxyamphetamine (PHA) and p-hydroxybenzoic acid (PHBA) have been isolated by gas-liquid chromatography (GC) as urinary metabolites of p-methoxyamphetamine (PMA) in dogs and rhesus monkeys. The amounts of PMA excreted unchanged in the total 24-hr urine samples in dogs and monkeys were 26% and 3%, respectively, of the total administered doses. The amounts of the pharmacologically active metabolite PHA excreted in 24-hr urine samples were 13% in the dog and 44% in the monkey. In the dog, 72% of the PHA was present as free (unconjugated) PHA, whereas in the monkey the amount of PHA present in the free form was only 14%.
2.False negative hydroxyamphetamine test in horner syndrome caused by acute internal carotid artery dissection.
Moster ML;Galiani D;Garfinkle W J Neuroophthalmol. 2003 Mar;23(1):22-3.
A patient with Horner syndrome from internal carotid artery dissection initially had a false negative hydroxyamphetamine test. Two months later, the ophthalmic signs had disappeared but the hydroxyamphetamine test was positive. This case illustrates that hydroxyamphetamine testing may be falsely negative in acute Horner syndrome because norepinephrine stores in oculosympathetic postganglionic terminals have not yet been depleted. However, the hydroxyamphetamine test may be positive even after the ophthalmic signs of Horner syndrome have disappeared.
3.High performance liquid chromatography with chemiluminescence detection of methamphetamine and its related compounds using 4-(N,N-dimethylaminosulphonyl)-7-fluoro-2,1,3-benzoxadiazole.
Nakashima K;Suetsugu K;Yoshida K;Akiyama S;Uzu S;Imai K Biomed Chromatogr. 1992 May-Jun;6(3):149-54.
A high performance liquid chromatographic assay of methamphetamine (MP) and its related compounds, i.e. ephedrine (EP), norephedrine (NE), p-hydroxymethamphetamine (p-HMP), p-hydroxyamphetamine (p-HAP) and amphetamine (AP), with peroxyoxalate chemiluminescence detection has been developed. 4-(N,N-Dimethylaminosulphonyl)-7-fluoro-2,1,3-benzoxadiazole (DBD-F) was used as a fluorescent labeling reagent. A mixture of hydrogen peroxide and bis[4-nitro-2-(3,6,9-trioxadecyloxycarbonyl)phenyl] oxalate in acetonitrile was used as a postcolumn chemiluminogenic reagent. DBD derivatives of MP and its related compounds were separated by a gradient elution with acetonitrile and 0.01 M imidazole buffer (pH 7.0) within 65 min. The detection limits (S/N = 3) for the proposed method for MP, AP, EP, NE, p-HMP and p-HAP were 27, 100, 40, 133, 25 and 133 fmol on column, respectively. The recoveries of these compounds with normal urine samples were 87.4-106.4%. The method was successfully applied to the assay of MP and its metabolites in urine samples from MP addicts. A good linear correlation for the resulted amounts of MP or AP between the proposed method and gas chromatography was obtained (r = 0.993 for MP or 0.
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Chemical Structure

CAS 103-86-6 4-(2-aminopropyl)phenol

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