|Description||3-MATIDA is a potent metabotropic glutamate (mGlu1) receptor antagonist with IC50 value of 6.3 μM at rat mGlu1a. It displays ≥ 40-fold selectivity over other receptors. It has neuroprotective activity in cultured murine cortical cells and rat hippocampal slice cultures in vitro. It reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo.|
|Purity||≥99% by HPLC|
|Synonyms||α-Amino-5-carboxy-3-methyl-2-thiopheneaceticacid; 5-[amino(carboxy)methyl]-4-methylthiophene-2-carboxylic acid; 3-Methyl-aminothiophene dicarboxylic acid|
ACPT-II has been found to be a mGluR antagonist and could probably exhibit neuroprotective effects.
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LY 367385 is a selective mGlu1a receptor antagonist with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis. LY 367385 is u...
(RS)-APICA has been found to be a group II metabotropic glutamate receptor antagonist and could increase extracellular glutamate concentrations and possesses un...
LY 456236 hydrochloride
LY 456236 hydrochloride is a mGlu1 receptor antagonist with IC50 value of 143 nM. It may be used in the treatment of chronic pain.
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Very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to lo...