3-Epicorosolic acid - CAS 52213-27-1
Catalog number: B0005-399068
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3-Epicorosolic acid isolated from the dried fruit of Ziziphus jujuba. It has a potent inhibitory effect on EBV-EA induction and shows mixed type inhibition against PTP1B, while it shows uncompetitive inhibition against α-glucosidase.
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B0005-399068 1 mg $399 In stock
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(2alpha,3alpha)-2,3-Dihydroxy-urs-12-en-28-oic acid; Pygenic acid A;
anti-inflammatory; anti-tumor;
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1.Intake of a Western diet containing cod instead of pork alters fatty acid composition in tissue phospholipids and attenuates obesity and hepatic lipid accumulation in mice.
Liisberg U1, Fauske KR2, Kuda O3, Fjære E2, Myrmel LS2, Norberg N2, Frøyland L2, Graff IE2, Liaset B2, Kristiansen K4, Kopecky J3, Madsen L5. J Nutr Biochem. 2016 Apr 1;33:119-127. doi: 10.1016/j.jnutbio.2016.03.014. [Epub ahead of print]
The content of the marine n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is far lower in lean than in fatty seafood. Cod filets contain less than 2g fat per kg, whereof approximately 50% is EPA and DHA. However, a large fraction of these n-3 PUFAs is present in the phospholipid (PL) fraction and may have high bioavailability and capacity to change the endocannabinoid profile. Here we investigated whether exchanging meat from a lean terrestrial animal with cod in a background Western diet would alter the endocannabinoid tone in mice and thereby attenuate obesity development and hepatic lipid accumulation. Accordingly, we prepared iso-caloric diets with 15.1 energy (e) % protein, 39.1 e% fat and 45.8 e% carbohydrates using freeze-dried meat from cod filets or pork sirloins, and using a combination of soybean oil, corn oil, margarine, milk fat, and lard as the fat source. Compared with mice receiving diets containing pork, mice fed cod gained less adipose tissue mass and had a lower content of hepatic lipids.
2.Neuroprotective effect of Picholine virgin olive oil and its hydroxycinnamic acids component against β-amyloid-induced toxicity in SH-SY5Y neurotypic cells.
Villareal MO1,2, Sasaki K1, Margout D3, Savry C3, Almaksour Z3, Larroque M3, Isoda H4,5. Cytotechnology. 2016 May 7. [Epub ahead of print]
The health benefits of Mediterranean diet has long been reported and attributed to the consumption of virgin olive oil (VOO). Here, we evaluated the neuroprotective effect of VOO against Alzheimer's disease by determining its effect on β-amyloid (Aβ)-induced cytotoxicity and oxidative stress, and explored the possibility that its hydroxycinnamic acids (Hc acids) content contribute significantly to this effect. SH-SY5Y cells treated with or without Aβ and with VOO or Hc acids (mixture of p-coumaric acid, ferulic acid, vanillic acid, and caffeic acid) were subjected to MTT assay and the results showed that both samples alleviated Aβ-induced cytotoxicity. Furthermore, both VOO and Hc acids decreased the reactive oxygen species level. Using western blot to determine the effect of these samples on Aβ-induced activation of pERK1/2, p38, and JNK MAPKs, results revealed that both VOO and Hc acids inhibited the activation of pERK1/2 and p-p38 MAPK, but not JNK.
3.Synthesis, molecular properties prediction and cytotoxic screening of 3-(2-aryl-2-oxoethyl)isobenzofuran-1(3H)-ones.
da Silva Maia AF1, Siqueira RP2, de Oliveira FM3, Ferreira JG2, da Silva SF1, Caiuby CA1, de Oliveira LL4, de Paula SO4, Souza RA5, Guilardi S5, Bressan GC6, Teixeira RR7. Bioorg Med Chem Lett. 2016 Apr 25. pii: S0960-894X(16)30441-3. doi: 10.1016/j.bmcl.2016.04.065. [Epub ahead of print]
In the present investigation, a collection of nineteen 3-(2-aryl-2-oxoethyl)isobenzofuran-1(3H)-ones was synthesized and screened for their cytotoxic activity against a panel of three leukemia cancer cell lines. The compounds were prepared via ZrOCl2·8H2O catalyzed condensation reactions between phthalaldehydic acid and different acetophenones. The reactions were carried out free of solvent and the isobenzofuran-1(3H)-ones were obtained in good yields (80-92%). The identities of the synthesized compounds were confirmed upon IR and NMR (1H and 13C) spectroscopy as well as high resolution mass spectrometry analyses. Structures of compounds 1, 4 and 16 were also investigated by X-ray analysis. The synthesized compounds were submitted to in vitro bioassays against HL-60, K562 and NALM6 cancer cell lines using MTT cytotoxicity assay. After 48h of treatment, twelve derivatives were able to reduce cell viability and presented IC50 values equal to or below 20μmolL-1 against at least one of the evaluated lineages.
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CAS 52213-27-1 3-Epicorosolic acid

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