29-Hydroxyfriedelan-3-one - CAS 39903-21-4
Catalog number: 39903-21-4
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C30H50O2
Molecular Weight:
442.7
COA:
Inquire
Chemical Family:
Triterpenoids
Description:
29-Hydroxyfriedelan-3-one isolated from the herbs of Euonymus alatus (Thunb.) Sieb.
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Purity:
> 95%
Appearance:
Powder
Synonyms:
3-Oxo-29-hydroxyfriedelane;Friedelane-3-one-29-ol
MSDS:
Inquire
Quality Standard:
Enterprise Standard
Quantity:
Milligrams-Grams
1.Triterpenes from Tripterygium wilfordii Hook.
Yang JH;Luo SD;Wang YS;Zhao JF;Zhang HB;Li L J Asian Nat Prod Res. 2006 Jul-Aug;8(5):425-9.
Two new friedelane-type triterpenes, tripterfrielanons A (1) and B (2), along with six known triterpenoids, friedelin (3), canophyllal (4), canophyllalic acid (5), 3-oxo-29-hydroxyfriedelane (6), wilforlide A (7), wilforlide B (8), have been isolated from the EtOH extract of the roots of Tripterygiumwilfordii Hook.f. Compounds 4, 5, 6 were isolated for the first time from this plant. The new triterpenes 1 and 2 exhibited mild cytotoxic activity against human Hela cell lines in vitro. The assay showed the IC50 of 1 and 2 were 8.5 and 25 microg/mL, respectively.
2.Friedelane triterpenoids from Maytenus macrocarpa.
Chávez H;Estévez-Braun A;Ravelo AG;González AG J Nat Prod. 1998 Jan;61(1):82-5.
A set of friedelane triterpenoids has been isolated from the stem bark exudates of Maytenus macrocarpa. It includes a new friedelan triterpene (1), together with the known compounds friedelin, 3-oxo-29-hydroxyfriedelane, 3-oxofriedelan-25-al, and canophyllol. The structures of these compounds were elucidated by spectroscopic and chemical evidence. Complete 1H and 13C assignments were achieved by 2D NMR spectroscopy. The new compound showed weak activity against aldose reductase. It did not display antitumor activity against P-388 lymphoid neoplasm, A-549 human lung carcinoma, HT-29 human colon carcinoma, or MEL-28 human melanoma cell lines.
3.Triterpenes and phytosterols as human leucocyte elastase inhibitors.
Mitaine-Offer AC;Hornebeck W;Sauvain M;Zèches-Hanrot M Planta Med. 2002 Oct;68(10):930-2.
Ten triterpenes and phytosterols beta-amyrin, lupeol, lupeol acetate, ursolic acid, friedelin, canophyllol, 29-hydroxy-friedelan-3-one, beta-sitosterol, 3- O-beta- D-glucopyranosyl-beta-sitosterol, 3-O-(6'- O-palmitoyl)-beta-D-glucopyranosyl-beta-sitosterol, were evaluated as potential inhibitors of human leucocyte elastase (HLE). In this series, lupeol, ursolic acid and canophyllol showed marked HLE inhibitory activity with IC(50) values at 1.9 microM, 4.4 microM, and 2.5 microM, respectively. It appeared that HLE inhibition depended on the presence and the orientation of two reactive groups in the tested molecules, distant from 10-12 A, reacting with Arg-217 in S(4) -S(5) subsites of the extended substrate-binding domain of HLE, and S(3), respectively.
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Chemical Structure

CAS 39903-21-4 29-Hydroxyfriedelan-3-one

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