(20S)-Protopanaxadiol - CAS 30636-90-9
Catalog number:
30636-90-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C30H52O3
Molecular Weight:
460.73
COA:
Inquire
Targets:
Apoptosis Inducer
Description:
Protopanaxdiol, an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin extracted from the roots of Panax ginseng C. A. Mey. It is apoptosis inducer wth anti-tumor effect that was used to induce cytotoxicity for two human glioma cell l
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Purity:
>98%
Appearance:
White powder
Synonyms:
(3S,5R,8R,9R,10R,12R,13R,14R,17S)-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol 20(S)-protopanaxadiol protopanaxadiol protopanaxadiol, (3beta,12beta)-iso
Solubility:
Soluble to 40 mg/ml in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -72℃ for long term (months to years).
MSDS:
Inquire
Quality Standard:
Enterprise Standard
Shelf Life:
2 years
Quantity:
Milligrams-Grams
Boiling Point:
559.5±40.0 °C | Condition: Press: 760 Torr
Melting Point:
197-200 °C
Density:
1.036±0.06 g/cm3
InChIKey:
PYXFVCFISTUSOO-HKUCOEKDSA-N
InChI:
1S/C30H52O3/c1-19(2)10-9-14-30(8,33)20-11-16-29(7)25(20)21(31)18-23-27(5)15-13-24(32)26(3,4)22(27)12-17-28(23,29)6/h10,20-25,31-33H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24-,25-,27-,28+,29+,30-/m0/s1
Canonical SMILES:
CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)O)C)C)O)C)O)C
1.Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet.
Liu R1, Zhang J, Liu W, Kimura Y, Zheng Y. Fitoterapia. 2010 Dec;81(8):1079-87. doi: 10.1016/j.fitote.2010.07.002. Epub 2010 Aug 19.
Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. PDG inhibited the pancreatic lipase activity in a dose-dependent manner at the concentrations of 0.25-1mg/ml. It inhibited hydrolysis of about 83.2% of triolein at about 1mg/ml of PDG. However, PTG showed no inhibitory activity. Therefore, anti-obesity activity of PDG was evaluated in mice fed a high-fat diet. The results demonstrated that PDG was effective in preventing and healing obesity, fatty liver and hypertriglyceridemia in mice fed with a high-fat diet.
2.Selected ginsenosides of the protopanaxdiol series are novel positive allosteric modulators of P2X7 receptors.
Helliwell RM1, ShioukHuey CO2, Dhuna K2, Molero JC1, Ye JM1, Xue CC1, Stokes L2,3. Br J Pharmacol. 2015 Jul;172(13):3326-40. doi: 10.1111/bph.13123. Epub 2015 Apr 24.
BACKGROUND AND PURPOSE: The P2X7 receptor is an ATP-gated ion channel predominantly expressed in immune cells and plays a key role in inflammatory processes. Ginseng is a well-known Chinese herb with both pro- and anti-inflammatory properties and many of its actions have been ascribed to constituent ginsenosides. We screened a number of ginsenoside compounds for pharmacological activity at P2X7 receptors, that might contribute to the reported immunomodulatory actions of ginseng.
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CAS 30636-90-9 (20S)-Protopanaxadiol

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