|Description||2-Phenylmelatonin is an antagonist of the MEL-1A-R, MEL-1B-R, MT3, observed to demonstrate mixed antagonist/agonist activity in systems with differential expression of the receptor subtypes. And it is a highly potent melatonin agonist and displays higher affinity and greater potency than melatonin itself.|
|Purity||≥98% by HPLC|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
Tasimelteon (trade name Hetlioz) is a drug approved by the FDA solely for the treatment of non-24-hour sleep–wake disorder (often designated as N24HSWD) in tota...
Ramelteon has high affinity with recombinant human MT1 and MT2 receptors with pKi of 10.05 and 9.70, respectively.
6-Chloromelatonin is a potent agonist of the melatonin receptors, which is active at nanomolar concentrations. It shows higher affinity for binding to hamster b...
GR 135531 is a high affinity agonist of MT3 melatonin receptors, with low affinity for MT1 and MT2 melatonin receptors. GR 135531 can be used to discriminate be...
8-M-PDOT is a melatonin receptor agonist, with 20-fold selective for the MT2 (vs MT1) subtype (pKi = 8.23 and 8.95 at human recombinant MT1 and MT2 receptors re...
AH 001 is a potent melatonin agonist.
DH 97 is a selective MEL-1B-R (melatonin receptor) antagonist.
2-Iodomelatonin is a potent agonist of the melatonin receptors 1 (MT1) with Ki value of 28 pM. It could be used to identify, characterize and localize melatonin...