2-METHYLENE-1,3-DIOXEPANE - CAS 69814-56-8
Catalog number: 69814-56-8
Category: Intermediates
Molecular Formula:
Molecular Weight:
2-METHYLENE-1,3-DIOXEPANE; 3-METHYLENE-1,3-DIOXEPANE; 2-Methylene-4,5,6,7-tetrahydro-1,3-dioxepin
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1.Surface-Functionalized Biodegradable Nanoparticles Consisting of Amphiphilic Graft Polymers Prepared by Radical Copolymerization of 2-Methylene-1,3-Dioxepane and Macromonomers.
Asoh TA1, Nakajima T1, Matsuyama T1, Kikuchi A1. Langmuir. 2015 Jun 23;31(24):6879-85. doi: 10.1021/acs.langmuir.5b01149. Epub 2015 Jun 12.
Biodegradable polyester-based nanoparticles were prepared by the precipitation of amphiphilic graft copolymers, which were prepared by the ring-opening radical copolymerization of 2-methylene-1,3-dioxepane (MDO) and amphiphilic macromonomers. The diameter of the nanoparticles was controlled by the degree of grafting and the molecular weight of the grafting oligomer. PMDO-g-poly(ethylene glycol) nanoparticles were degraded by the alkaline hydrolysis of the polyester backbone. Although the colloidal stability of nanoparticles was retained due to the reorientation of the PEG chains during hydrolysis, the size of the nanoparticles decreased with increasing hydrolysis time. We also prepared PMDO-g-poly(N-isopropylacrylamide) nanoparticles, which show aggregation in response to increasing temperature.
2.Copolymerization of 2-methylene-1,3-dioxepane and glycidyl methacrylate, a well-defined and efficient process for achieving functionalized polyesters for covalent binding of bioactive molecules.
Undin J1, Finne-Wistrand A, Albertsson AC. Biomacromolecules. 2013 Jun 10;14(6):2095-102. doi: 10.1021/bm4004783. Epub 2013 May 15.
The understanding of cell-material interactions is important for creating personalized implants for tissue engineering. This has resulted in an interest in developing polymers with functional groups with the possibility of controlling the macromolecular surface. We have in a one-pot reaction synthesized a series of amorphous and degradable polyester-based copolymers with active functional groups by copolymerization of 2-methylene-1,3-dioxepane and glycidyl methacrylate. The properties of the final polymers were varied by varying the feed ratios of the monomers, and it was seen that it was possible to control the amount of active functional groups. The resulting epoxy-functionalized polyester was further modified by covalent immobilization of heparin. The heparinization was done in order, in a future aspect, to enhance the osteogenic differentiation of mesenchymal stem cells. Heparin binds directly with the growth factor bone morphogenetic protein-2 and helps to retain its activity.
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