2-Iminopiperidine hydrochloride - CAS 16011-96-4
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C5H11N2Cl
Molecular Weight:
134.61
COA:
Inquire
Targets:
Nitric oxide synthase (NOS)
Description:
2-Iminopiperidine hydrochloride is the hydrochloride salt of 2-Iminopiperidine, which is a potent inhibitor of human nitric oxide synthase isoform (iNOS). It is selective for iNOS and is more potent than NG-methyl-L-arginine.
Synonyms:
(3,4,5,6-Tetrahydropyridin-2-yl)amine Monohydrochloride
MSDS:
Inquire
InChIKey:
ZHDTXTDHBRADLM-UHFFFAOYSA-N
InChI:
InChI=1S/C5H10N2.ClH/c6-5-3-1-2-4-7-5;/h1-4H2,(H2,6,7);1H
Canonical SMILES:
C1CCN=C(C1)N.Cl
1.Design, synthesis, and neurochemical evaluation of 2-amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydropyridines and 2-amino-5-(alkoxycarbonyl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.
Dunbar PG;Durant GJ;Rho T;Ojo B;Huzl JJ 3rd;Smith DA;el-Assadi AA;Sbeih S;Ngur DO;Periyasamy S J Med Chem. 1994 Aug 19;37(17):2774-82.
Four regioisomers of 2-amino-(methoxycarbonyl)-3,4,5,6-tetrahydropyridine (2a-5a) were synthesized as the racemates to evaluate the utility of exocyclic amidines in the development of novel agonists for M1 muscarinic receptors. Of the four regioisomers, only racemic 2-amino-5-(methoxycarbonyl)-3,4,5,6-tetrahydropyridine (4a; CDD-0075-A) displayed high affinity (IC50 = 10 +/- 3.0 microM) and activity at muscarinic receptors coupled to PI metabolism in the rat cortex (260 +/- 4.5% stimulation above basal levels at 100 microM). A series of 2-amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydropyridines then was synthesized for further evaluation as M1 agonists. Only the propargyl derivative (4d) retained substantial agonist activity (120 +/- 14% at 100 microM) in this series. On the basis of the activity of the 5-(alkoxycarbonyl)-1,4,5,6- tetrahydropyrimidines (1a and 1d) and the 2-amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydropyridines, the corresponding cyclic guanidine derivatives were synthesized and tested. 2-Amino-5-(methoxycarbonyl)-1,4,5,6-tetrahydropyrimidine (7a) displayed a modest affinity for muscarinic receptors in the CNS (22 +/- 5.3 microM) and an ability to stimulate PI turnover in rat cerebral cortex (81 +/- 16% at 100 microM).
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Nitric oxide synthase (NOS) Products


CAS 137361-05-8 Nω-Propyl-L-arginine hydrochloride

Nω-Propyl-L-arginine hydrochloride
(CAS: 137361-05-8)

Nω-Propyl-L-arginine hydrochloride is a neuronal selective nitric oxide synthase inhibitor and a potent and selective inhibitor of NOS1 (nNOS) (Ki = 57 nM) with...

Ronopterin
(CAS: 206885-38-3)

Ronopterin is a potent Nitric oxide synthase inhibitor used as a neuroprotectant.

CAS 866914-87-6 ARL 17477 dihydrochloride

ARL 17477 dihydrochloride
(CAS: 866914-87-6)

The hydrochloride salt form of ARL 17477, which has been found to be a nitric oxide synthase (NOS) inhibitor and could induce apoptosis/cell death in leukemia c...

CAS 214358-33-5 1400W dihydrochloride

1400W dihydrochloride
(CAS: 214358-33-5)

1400W is a selective inducible nitric oxide synthase (NOS) inhibitor(Ki=7nM).By suppressing the induction of inducible NOS, 1400W exhibits an therapeutical effe...

CAS 62949-77-3 Kuwanon A

Kuwanon A
(CAS: 62949-77-3)

Kuwanon A, a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.), inhibits nitric oxide production (IC50= 10.5 μM).

CAS 56-06-4 2,4-Diamino-6-hydroxypyrimidine

2,4-Diamino-6-hydroxypyrimidine
(CAS: 56-06-4)

2,4-Diamino-6-hydroxypyrimidine has been found to be a GCH1 inhibitor and could suppress the activity of NO synthase through preventing the synthesis of BH4.

CAS 16011-96-4 2-Iminopiperidine hydrochloride

2-Iminopiperidine hydrochloride
(CAS: 16011-96-4)

2-Iminopiperidine hydrochloride is the hydrochloride salt of 2-Iminopiperidine, which is a potent inhibitor of human nitric oxide synthase isoform (iNOS). It is...

CAS 210354-22-6 GW 274150

GW 274150
(CAS: 210354-22-6)

GW 274150 is a potent, long-acting and highly selective inhibitor of iNOS which have a very high degree of selectivity for iNOS versus both eNOS (>100-fold) and...

Chemical Structure

CAS 16011-96-4 2-Iminopiperidine hydrochloride

Quick Inquiry

Verification code

Featured Items