2-Ethylhexyl salicylate - CAS 118-60-5
Catalog number:
118-60-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H22O3
Molecular Weight:
250.34
COA:
Inquire
Targets:
Others
Description:
2-Ethylhexyl salicylate could be commonly used in cosmetics and sunscreens acting as a skin penetration enhancer and could absorb UVB rays at some extent.
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Purity:
95%
Appearance:
clear to pale yellow liquid
Synonyms:
2-hydroxy-benzoicaci2-ethylhexylester;Benzoic acid, 2-hydroxy-, 2-ethylhexyl ester;Benzoicacid,2-hydroxy-,2-ethylhexylester;Dermoblock OS;Escalol 587;Ethylhexyl salicylate
Solubility:
DMSO: ≥ 2.7 mg/mL
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
2-Ethylhexyl salicylate could be commonly used in cosmetics and sunscreens acting as a skin penetration enhancer and could absorb UVB rays at some extent.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Boiling Point:
189-190ºC (21 mmHg)
Density:
1.014
InChIKey:
FMRHJJZUHUTGKE-UHFFFAOYSA-N
InChI:
InChI=1S/C15H22O3/c1-3-5-8-12(4-2)11-18-15(17)13-9-6-7-10-14(13)16/h6-7,9-10,12,16H,3-5,8,11H2,1-2H3
Canonical SMILES:
CCCCC(CC)COC(=O)C1=CC=CC=C1O
1.New Hybrid Organic/Inorganic Polysilsesquioxane-Silica Particles as Sunscreens.
Tolbert SH1, McFadden PD1, Loy DA1. ACS Appl Mater Interfaces. 2016 Feb 10;8(5):3160-74. doi: 10.1021/acsami.5b10472. Epub 2016 Jan 28.
Effectiveness of organic sunscreens is limited by phototoxicity and degradation. Both of which can be significantly reduced by encapsulation in hollow particles or covalent incorporation into the solid structure of particles, but direct comparisons of the two methods have not been reported. In this study, physical encapsulation and covalent incorporation of sunscreens were compared with 1 mol % salicylate and curcumeroid sunscreens. 2-Ethylhexyl salicylate was physically encapsulated in hollow silica nanoparticles prepared by oil-in-water (O/W) microemulsion polymerizations (E-Sal). Some of these particles were coated with an additional shell or cap of silica to reduce leaking of sunscreen (cap-E-Sal). Covalent incorporation involved co-polymerizing tetraethoxysilane (TEOS) with 0.2 mol % of new salicylate and curcuminoid sunscreen monomers with triethoxsilyl groups. Particles were prepared with the salicylate attached to the silica matrix through single silsesquioxane groups (pendant; P-Sal) and two silsesquioxane groups (bridged; B-Sal).
2.The difficulties for a photolabile drug in topical formulations: the case of diclofenac.
Ioele G1, De Luca M2, Tavano L2, Ragno G2. Int J Pharm. 2014 Apr 25;465(1-2):284-90. doi: 10.1016/j.ijpharm.2014.01.030. Epub 2014 Feb 1.
Topical commercial formulations containing diclofenac (DC) were submitted to photostability tests, according to the international rules, showing a clear degradation of the drug. The degradation process was monitored by applying the multivariate curve resolution technique to the UV spectral data from samples exposed to stressing irradiation. This method was able to estimate the number of components evolved as well as to draw their spectra and concentration profiles. Three photoproducts (PhPs) were resolved by the analysis of photodegradation kinetics, according to two consecutive reactions with a mechanism postulated as DC>PhP₁>PhP₂ and PhP₃. Photodegradation rate of DC in gel was found to be very fast, with a residual content of 90% only after 3.90 min under a radiant exposure of 450 Wm(-2). Because of a very slow skin uptake of DC, a prolonged time of exposure to light could lead to a significant decrease of drug available or the uptake of undesired photoproducts.
3.Allergic contact dermatitis from ethylhexyl salicylate.
Miralles JC, Escudero AI, Carbonell A, Martínez A, Fernández E, Cardona P. J Investig Allergol Clin Immunol. 2015;25(1):66-7.
4.Seasonal and diurnal variation of organic ultraviolet filters from personal care products used along the Japanese coast.
Sankoda K1, Murata K, Tanihata M, Suzuki K, Nomiyama K, Shinohara R. Arch Environ Contam Toxicol. 2015 Feb;68(2):217-24. doi: 10.1007/s00244-014-0106-7. Epub 2014 Dec 6.
This study aimed to investigate the behavior of organic ultraviolet (UV) filters released by recreational activities along the Japanese coastline. Seasonal variations of organic UV filters in seawater were investigated at four different recreational beaches (Mogushi, Wakamiya, Tsurugahama, and Otachimisaki beaches) in both summer (July through August) and winter (December). Moreover, short time scale diurnal changes were monitored at Otachimisaki beach in summer. Of the four sunscreen agents tested in this study, two agents-2-ethylhexyl-4-methoxycinnamate (EHMC) and 2-ethylhexyl salicylate (EHS)-were detected in all samples, whereas octyl-dimethyl-p-aminobenzonic acid and 3-(4-methylbenzylidene)-camphor were lower than detection limits. In particular, EHMC, one of the most popular organic UV filters, was dominant. The highest concentration of EHMC was observed at 1,080 ng L(-1), a level that exceeds those of previous studies. Both EHMC and EHS concentrations showed significant (p < 0.
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Chemical Structure

CAS 118-60-5 2-Ethylhexyl salicylate

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