2(acute)-Deoxyguanosine - CAS 961-07-9
Catalog number: 961-07-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
2(acute)-Deoxyguanosine is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose. It is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). It is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. It is useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.
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Deoxyguanosine; Guanine deoxyriboside
1.Acute kidney injury in high-risk cardiac surgery patients: roles of inflammation and coagulation.
Scrascia G1, Rotunno C, Simone S, Montemurno E, Amorese L, De Palo M, Castellano G, Pertosa GB, Gesualdo L, Paparella D. J Cardiovasc Med (Hagerstown). 2015 Dec 11. [Epub ahead of print]
AIMS: Acute kidney injury (AKI) is a common complication following cardiac surgery. Cardiopulmonary bypass elicits coagulation and inflammation activation and oxidative stress, all involved in AKI but never simultaneously assessed. We aimed to evaluate relations between oxidative stress, inflammatory and coagulation systems activation and postoperative renal function in patients with normal preoperative renal function.
2.Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass.
Funamoto M1, Masumoto H1, Takaori K2, Taki T1, Setozaki S1, Yamazaki K1, Minakata K1, Ikeda T3, Hyon SH4, Sakata R1. Ann Thorac Surg. 2016 Apr;101(4):1507-13. doi: 10.1016/j.athoracsur.2015.09.080. Epub 2015 Dec 8.
BACKGROUND: Acute kidney injury (AKI) is a common complication accompanying cardiopulmonary bypass (CPB) and is independently associated with increased morbidity and death. Diabetes mellitus increases the risk for AKI after CPB. Epigallocatechin-3-gallate (EGCG) is a major component of the polyphenolic fraction of green tea, which possesses cardioprotective activities, as previously reported. We hypothesized that EGCG also possesses a renoprotective effect through its diverse biochemical properties and assessed the effect on renal function after CPB for diabetic rats.
3.Resveratrol alleviates the cytotoxicity induced by the radiocontrast agent, ioxitalamate, by reducing the production of reactive oxygen species in HK-2 human renal proximal tubule epithelial cells in vitro.
Huang YT1, Chen YY2, Lai YH3, Cheng CC4, Lin TC4, Su YS3, Liu CH5, Lai PC6. Int J Mol Med. 2016 Jan;37(1):83-91. doi: 10.3892/ijmm.2015.2404. Epub 2015 Nov 9.
Radiocontrast-induced nephropathy (RIN) is one of the leading causes of hospital-acquired acute kidney injury (AKI). The clinical strategies currently available for the prevention of RIN are insufficient. In this study, we aimed to determine whether resveratrol, a polyphenol phytoalexin, can be used to prevent RIN. For this purpose, in vitro experiments were performed using a human renal proximal tubule epithelial cell line (HK-2 cells). Following treatment for 48 h, the highly toxic radiocontrast agent, ioxitalamate, exerted cytotoxic effects on the HK-2 cells in a concentration-dependent manner, as shown by MTT assay. The half maximal inhibitory concentration (IC50) was found to be approximately 30 mg/ml. Flow cytometry also revealed a marked increase in the number of apoptotic cells following exposure to ioxitalamate. In addition, the number of necrotic, but not necroptotic cells was increased. However, treatment with resveratrol (12.
4.Increased activities of both superoxide dismutase and catalase were indicators of acute depressive episodes in patients with major depressive disorder.
Tsai MC1, Huang TL2. Psychiatry Res. 2016 Jan 30;235:38-42. doi: 10.1016/j.psychres.2015.12.005. Epub 2015 Dec 8.
Oxidative stress may play an important role in the pathophysiology of major depressive disorder (MDD). The aim of this study was to investigate the serum levels of oxidative stress biomarkers and S100B in patients with MDD in an acute phase, and evaluate the changes in superoxide dismutase (SOD), protein carbonyl content (PCC), glutathione peroxidase (GPX), 8-hydroxy 2'-deoxyguanosine after treatment (8-OHdG), catalase (CAT), thiobarbituric acid reactive substances (TBARS) and S100B. We consecutively enrolled 21 MDD inpatients in an acute phase and 40 healthy subjects. Serum oxidative stress markers were measured with assay kits. Serum SOD and CAT activities in MDD patients in an acute phase were significantly higher than those of healthy subjects, and serum PCC levels were significantly lower. The HAM-D scores had a significantly positive association with S100B levels. Eighteen depressed patients were followed up, and there was no significant difference among all of the markers after treatment.
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CAS 961-07-9 2(acute)-Deoxyguanosine

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