|Description||This molecular is a [18F] PET (positron emission tomography) radiotracer. It can accumulate in cells presenting apoptosis-specific membrane alterations. ML-10 allows for the detection of apoptotic cells located in atherosclerotic plaques. In Jun 2015, GlaxoSmithKline terminated a phase II trial in Solid tumours (Diagnosis) in United Kingdom. In Mar 2016, Phase-II for solid tumours, lung cancer and head Brain metastases and neck cancer (Diagnosis) in USA was suspended|
|Synonyms||ML 10;[18F]-ML-10; ApoSense-PET; F-18-ML-10;|
|Solubility||Soluble in DMSO|
|Application||used as an Cancer Diagnostic reagents|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||Aposense; GlaxoSmithKline|
Troxipide is a novel systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting properties irrespective of p...
Dithioerythritol, a sulfur containing sugar derived from the corresponding 4-carbon monosaccharide erythrose, is an epimer of dithiothreitol(DTT).
SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide...
Ceftobiprole is a cephalosporin prodrug with potent bactericidal activity against methicillin-resistant MRSA and penicillin-resistant Streptococcus pneumoniae (...
Isochlorogenic acid C
Source from The herbs of Laggera alata, Isochlorogenic acid C is a selective inhibitor of human immunodeficiency virus type 1 integrase.
THK5351 R enantiomer is an R enantiomer of THK5351 which can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain and bou...
CGP 43182, a dioxaspiro compound, has been found to a IIA sPLA2 inhibitor that could have potential anti-inflammatory effect and also in influencing the synergi...
BTZO 1 is a macrophage migration inhibitory factor (MIF) binder (Kd = 68.6 nM). BTZO 1 activates antioxidant response element (ARE)-mediated gene expression and...
Quinine is a primary alkaloid of various species of Cinchona. Because of its relatively constant and well-known fluorescence quantum yield, quinine is also used...
Trapidil, also called as Rocornal, is a platelet aggregation inhibitor with specific platelet-derived growth factor.
TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines, activated the transcriptional activity in a manner dependent o...
Tirapazamine is a benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free rad...
Chitinase-IN-1 is a insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide; 50 uM/20uM compound concentration's inhibitory percentage are 75%...
Angiotensin 1 Human
Angiotensin 1 (Human), an endogenous peptide substrate for angiotensin converting enzyme (ACE), is precursor to the vasoconstrictor peptide angiotensin II.
Tiopronin is a US Food and Drug Administration (FDA)-approved drug for the treatment of cystinuria by controlling the rate of cystine precipitation and excretio...
Schisandrin B(Wuweizisu-B) is a dibenzocyclooctadiene derivative isolated from Fructus Schisandrae, has been shown to produce antioxidant effect on rodent liver...
Cysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells.
Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.
Dirlotapide is a drug used to treat obesity in dogs works as a gut-selective microsomal triglyceride transfer protein (MTTP or MTP) inhibitor.