2-(5-fluoropentyl)-2-methylmalonic acid - CAS 1216897-16-3
Catalog number: 1216897-16-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C9H15FO4
Molecular Weight:
206.21
COA:
Inquire
Targets:
Others
Description:
This molecular is a [18F] PET (positron emission tomography) radiotracer. It can accumulate in cells presenting apoptosis-specific membrane alterations. ML-10 allows for the detection of apoptotic cells located in atherosclerotic plaques. In Jun 2015, GlaxoSmithKline terminated a phase II trial in Solid tumours (Diagnosis) in United Kingdom. In Mar 2016, Phase-II for solid tumours, lung cancer and head Brain metastases and neck cancer (Diagnosis) in USA was suspended
Purity:
98%
Appearance:
Powder
Synonyms:
ML 10;[18F]-ML-10; ApoSense-PET; F-18-ML-10;
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
used as an Cancer Diagnostic reagents
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
BOYGOAXVKOOCKN-UHFFFAOYSA-N
InChI:
InChI=1S/C9H15FO4/c1-9(7(11)12,8(13)14)5-3-2-4-6-10/h2-6H2,1H3,(H,11,12)(H,13,14)
Canonical SMILES:
CC(CCCCCF)(C(=O)O)C(=O)O
Current Developer:
Aposense; GlaxoSmithKline
1.Inflammatory cytokines induce protein tyrosine nitration in rat astrocytes.
Görg B;Bidmon HJ;Keitel V;Foster N;Goerlich R;Schliess F;Häussinger D Arch Biochem Biophys. 2006 May 15;449(1-2):104-14. Epub 2006 Mar 9.
Protein tyrosine nitration may be relevant for the pathogenesis of hepatic encephalopathy (HE). Infections, sepsis, and trauma precipitate HE episodes. Recently, serum levels of tumor necrosis factor (TNF)-alpha were shown to correlate with severity of HE in chronic liver failure. Here the effects of inflammatory cytokines on protein tyrosine nitration in cultured rat astrocytes and rat brain in vivo were studied. In cultured rat astrocytes TNF-alpha (50 pg/ml-10 ng/ml) within 6h increased protein tyrosine nitration. TNF-alpha-induced tyrosine nitration was related to an increased formation of reactive oxygen and nitrogen intermediates, which was downstream from a NMDA-receptor-dependent increase of intracellular [Ca(2+)](i) and nNOS-catalyzed NO production. Astroglial tyrosine nitration was also elevated in brains of rats receiving a non-lethal injection of lipopolysaccharide, as indicated by colocalization of nitrotyrosine immunoreactivity with glial fibrillary acidic protein and glutamine synthetase, and by identification of the glutamine synthetase among the tyrosine-nitrated proteins. It is concluded that reactive oxygen and nitrogen intermediates as well as protein tyrosine nitration by inflammatory cytokines may alter astrocyte function in an NMDA-receptor-, Ca(2+)-, and NOS-dependent fashion.
2.The U937 cell line induced to express CD14 protein by 1,25-dihydroxyvitamin D3 and be sensitive to endotoxin stimulation.
Liu HZ;Gong JP;Wu CX;Peng Y;Li XH;You HB Hepatobiliary Pancreat Dis Int. 2005 Feb;4(1):84-9.
BACKGROUND: ;CD14 was first described as a differentiation antigen on the surface of myeloid lineage cells. It acts as a glycosylphosphatidylinositol (GPI)-anchored receptor for the complex of lipopolysaccharide (LPS) and plays a key role in the activation of LPS-induced monocytes. The purpose of this study was to observe the expression of CD14 protein and its gene in the human U937 promonocytic cell line when these cells were exposed to 1,25-dihydroxyvitamin D3(VitD3) and investigate their sensitivity to endotoxin stimulation.;METHODS: ;U937 cells were exposed to (0.1 micromol) VitD3 for 24 hours and were induced to express the CD14 mRNA gene and CD14 protein, then their responses were observed when they were stimulated with different concentrations of LPS for different time.;RESULTS: ;The U937 cells induced by VitD3 were found to stably express CD14 mRNA and CD14 protein. And CD14 protein enhanced the sensitivity of U937/CD14 cells to lipopolysaccharide (LPS) stimulation. NF-kappaB in U937/CD14 cells can be activated with low concentration of LPS (1 ng/ml-10 ng/ml), the TNF-alpha mRNA gene was induced, and then TNF-alpha was produced and released into the supernatant of culture.;CONCLUSION: ;VitD3 can induce U937 cell to express the CD14 gene and CD14 protein and enhance the response of this type of cells to LPS stimulation.
3.Simple method for the analysis of tenoxicam in human plasma using high-performance liquid chromatography.
Mason JL;Hobbs GJ J Chromatogr B Biomed Appl. 1995 Mar 24;665(2):410-5.
A simple, rapid and cost-effective method for the determination of tenoxicam in human plasma is described, using ketorolac as the internal standard. The extraction procedure utilised 5% zinc sulphate and methanol. A nucleosil C18 column and 35:65 acetonitrile-water phosphate buffered mobile phase (pH 2.8) were used, with ultraviolet detection at 355 nm. The assay was linear in the range 40 ng/ml-10 micrograms/ml, with recovery of extraction ranging from 87 to 102%. The intra- and inter-assay reproducibility had coefficients of variation of 3.9-7.7 and 1.6% respectively. The limit of detection for this method was 40 ng/ml.
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CAS 1216897-16-3 2-(5-fluoropentyl)-2-methylmalonic acid

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