2-(4-Hydroxyphenyl)ethanol - CAS 501-94-0
Catalog number: 501-94-0
Not Intended for Therapeutic Use. For research use only.
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2-(4-Hydroxyphenyl)ethanol isolated from the leaves of Canarium album.
4-Hydroxyphenethyl alcohol
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1.New lipophilic tyrosyl esters. Comparative antioxidant evaluation with hydroxytyrosyl esters.
Mateos R;Trujillo M;Pereira-Caro G;Madrona A;Cert A;Espartero JL J Agric Food Chem. 2008 Nov 26;56(22):10960-6. doi: 10.1021/jf8020267.
New lipophilic esters of tyrosol, a naturally occurring phenol with interesting biological properties, have been synthesized in good yields by a chemoselective procedure, using lipase from Candida antarctica or p-toluenesulfonic acid as catalysts. Their antioxidant activities have been evaluated by the Rancimat test in lipophilic food matrices, as well as by FRAP and ABTS assays in methanolic solutions, and compared with those of previously synthesized hydroxytyrosyl esters. Free tyrosol, hydroxytyrosol, butylhydroxytoluene, and alpha-tocopherol were used as standards. All methods used for the antioxidant activity evaluation emphasized the high influence of the ortho-diphenolic structure on the antioxidant capacity, tyrosol and its derivatives being less active than hydroxytyrosol and its analogues and even less than BHT and alpha-tocopherol. In addition, the Rancimat test revealed a lower activity for ester derivatives than for their respective reference compounds (HTy or Ty), in agreement with the polar paradox. On the other hand, FRAP and ABTS methods reported an opposite behavior between the synthetic esters and their respective references. Thus, hydroxytyrosyl esters were more active than HTy, whereas tyrosyl esters were less active than Ty.
2.Inhibition of mTOR/S6K1/4E-BP1 Signaling by Nutraceutical SIRT1 Modulators.
Bianchi S;Giovannini L Nutr Cancer. 2018 Apr;70(3):490-501. doi: 10.1080/01635581.2018.1446093. Epub 2018 Mar 14.
The mTOR pathway plays a crucial role in many human diseases, mostly associated with an over hyperactivity of the mTOR signaling, which makes its inhibitors potentially effective therapeutics. Thus, it is important to consider not only the mTOR pathway, but also all those factors that play a key role in its regulation, such as SIRT1 and AMPK. We previously demonstrated the role of some nutraceutical SIRT1 modulators in AMPK and mTOR pathway, showing the presence of a synergistic effect. Now we take further our research by evaluating the effect of berberine, quercetin, tyrosol, and ferulic acid on the mTOR/S6K1/4E-BP1 signaling, along with the existence of any synergistic effect between the following associations: berberine + tyrosol, tyrosol + ferulic acid, ferulic acid + quercetin. Our results indicate the existence of an important relationship between the substances tested and the pathway of mTOR/S6K1/4E-BP1, a report corroborated by the bond of mTOR with SIRT1/AMPK pathways and by their reciprocal regulation.
3.[Involvement of monoamine oxidases in formation of 4-hydroxyphenylethanol, major component of tribulin A].
Panova NG;Veselovskaia NV;Medvedev AE Vopr Med Khim. 1997 May-Jun;43(3):172-6.
Pathways of 4-hydroxyphenylethanol formation were studied in the bovine brain. Incubation of brain homogenates with tyramine or tyrosine increased 4-hydroxyphenylethanol content only in the presence of NADH. Tyramine produced more pronounced augmentation of 4-hydroxyphenylethanol content than tyrosine. Tyrosine preparations were not contamined with tyramine. This suggests that 4-hydroxyphenylethanol may be formed from tyramine and tyrosine in NADH-dependent process. Preincubation of homogenates with 0.1 mM pargyline completely inhibited monoamine oxidases A and B and prevented NADH-dependent formation of 4-hydroxyphenylethanol from tyramine. The latter suggests that MAO is involved in formation of 4-hydroxyphenylethanol.
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CAS 501-94-0 2-(4-Hydroxyphenyl)ethanol

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