2,3-Diaminonaphthalene - CAS 771-97-1
Category: Inhibitor
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Molecular Formula:
C10H10N2
Molecular Weight:
158.2
COA:
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Targets:
Nitric oxide synthase (NOS)
Description:
2,3 Diaminonaphthalene is a highly selective colorimetric and fluorometric reagent for selenium detection and also an inhibitor of nitric oxide (NO) formation.
Appearance:
Off-white to light brown solid
Synonyms:
naphthalene-2,3-diamine; 2,3-diaminonaphthalene; 2,3-naphthalenediamine
Solubility:
DMSO: ≥ 150 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
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Boiling Point:
370.6±15.0 ℃ at 760 Torr
Melting Point:
199 ℃
Density:
1.234±0.06 g/cm3
InChIKey:
XTBLDMQMUSHDEN-UHFFFAOYSA-N
InChI:
1S/C10H10N2/c11-9-5-7-3-1-2-4-8(7)6-10(9)12/h1-6H,11-12H2
Canonical SMILES:
C1=CC=C2C=C(C(=CC2=C1)N)N
1.Glyoxal and methylglyoxal determination in urine by surfactant-assisted dispersive liquid-liquid microextraction and LC.
Campillo N;Viñas P;Marín J;Hernández-Córdoba M Bioanalysis. 2017 Feb;9(4):369-379. doi: 10.4155/bio-2016-0217. Epub 2017 Jan 19.
AIM: ;Two important markers of oxidative stress, glyoxal and methylglyoxal, are preconcentrated from human urine by surfactant-assisted dispersive liquid-liquid microextraction and separated by LC-fluorescence.;METHODS/RESULTS: ;Derivatization was carried out overnight with 0.8 mM 2,3-diaminonaphthalene at 4°C. For surfactant-assisted dispersive liquid-liquid microextraction, 500 µl buffer solution (pH 10.5) and 25 µl 0.03 M Triton X-114 were added to 2.5 ml of the sample and the mixture was made up to 10 ml before the rapid injection of 75 µl 1-undecanol (extractant solvent) and 0.5 ml ethanol (dispersant solvent).;CONCLUSION: ;The method can be applied to analyze glyoxal and methylglyoxal in urine with LOD of 13 and 16 ng/l, respectively, and recoveries in the 88-103% range.
2.[A fluorospectrophotometric determination of nitrite in blood].
Fang BW;Jin ZH;Lin XZ Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2005 May;21(2):235-9.
AIM: ;To establish a fluorospectrophotometric assay for the measurement of nitrite in blood.;METHODS: ;Interference from hemoglobin and other blood ingredients was removed through sulfuric acid and phosphotungstic acid pretreatment. Fluorescence of 1-[H]-naphthotriazole from the reaction of 2,3-diaminonaphthalene with nitrite was determined with fluorospectrophotometry.;RESULTS: ;The following conditions were proper: Serum or plasma was treated with sulfuric acid and phosphotungstic acid pretreatment for two times, 2,3-diaminonaphthalene of 0.63 mmol x (L(-1)) was used, reaction solution pH and final pH were about 1.60 and 1.70 respectively, solution containing 2,3-diaminonaphthalene and supernatant after pretreatment was water-bathed at 20 degrees C for 15 minutes. The lower limit of detection was 24.27 nmol x L(-1). Nitrite determined in peripheral blood of healthy people was (10.91 +/- 2.38) micromol x L(-1), and its 95% distribution range was (6.24-15.57) micromol x L(-1).;CONCLUSION: ;It's a relatively sensitive, specific, simple method. It's of some value to the study of nitric oxide.
3.Improved molecular fluorescence method for the determination of selenium in biological samples.
Harrison I;Littlejohn D;Fell GS Analyst. 1996 Nov;121(11):1641-6.
A procedure for the determination of selenium in whole blood and urine has been improved by optimization of the digestion and derivatization procedures. An overnight pre-digestion step with 4 + 1 concentrated nitric-perchloric acids reduced the time of mineralization at 170 degrees C from 4 h to 30-45 min. Conversion of all the selenium to selenite (SeIV) was optimized by addition of 1 ml of concentrated hydrochloric acid, with heating to 100 degrees C for 30 min. The rate of formation of the 2,3-diaminonaphthalene (DAN) complex of selenium was improved by heating to 70-100 degrees C for a minimum of 30 min. Co-addition of hexane during derivatization simplified the extraction procedure. The modified method was applied successfully to the analysis of Seronorm quality control whole blood and urine (83 and 24 micrograms l-1 Se, respectively). Samples from 12 healthy adults, gave results in expected ranges (mean concentrations of 75 +/- 8 micrograms l-1 in blood and 25 +/- 8 micrograms l-1 in urine). The structure of the Se-DAN complex was investigated using elemental analysis, FTIR spectrometry, 1H and 13C NMR spectroscopy, and FAB MS. The information obtained indicates that the selenodiazo group does not contain an Se-O bond or protonated nitrogens, as proposed in other studies.
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CAS 771-97-1 2,3-Diaminonaphthalene

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