|Molecular Formula||C19H21Cl NO2Br|
|Description||1H-3-Benzazepine-7,8-diol,6-chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)-, hydrobromide (1:1) is a synthetic compound belongs to the benzazepine class . It acts as a D1/D5 receptor full agonist. It produces characteristic anorectic effects, hyperactivity and self-administration in animals, which is similar to but not identical with dopaminergic stimulants such as amphetamine. It could increase renal blood flow in animal models and promote contralateral rotation in rats with unilateral lesions of the substantia nigra. It also could augment GABAB inhibitory post-synaptic potentials in ventral tegmental area in brain slices. It also acts as an agonist of ERα with negligible activity at ERβ, making it a subtype-selective estrogen. In vivo, the acute injection of SKF-82958 would induce PPD, SP and PPE mRNA expression in the intact rat striatum.|
|Appearance||White to off-white Solid|
|Synonyms||6-Chloro-2,3,4,5-Tetrahydro-1-Phenyl-3-(2-Propen-1-Yl)-1H-3-Benzazepine-7,8-Diol Hydrobromide (1:1);SKF-82958 hydrobromide;(±)-SKF 82958 hydrobromide;Chloro-APB hydrobromide;(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine HBr|
|Solubility||H2O:＜ 6 mg/mL|
|Application||1H-3-Benzazepine-7,8-diol,6-chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)-, hydrobromide (1:1) produces characteristic anorectic effects, hyperactivity and self-administration in animals. It could increase renal blood flow in animal models and promote contralateral rotation in rats with unilateral lesions of the substantia nigra. It also could augment GABAB inhibitory post-synaptic potentials in ventral tegmental area in brain slices. It also acts as an agonist of ERα with negligible activity at ERβ, making it a subtype-selective estrogen.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Milligram to gram|
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