17α-Hydroxyprogesterone Caproate - CAS 630-56-8
Catalog number:
630-56-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C27H40O4
Molecular Weight:
428.6
COA:
Inquire
Targets:
Others
Description:
17α-Hydroxyprogesterone Caproate , a synthetic steroidal progestin, is an ester derivative of 17α-hydroxyprogesterone formed from caproic acid used in the treatment of threatened miscarriage, gynecological disorders such as dysmenorrhea, premenstrual synd
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Purity:
≥98%
Appearance:
White powder
Synonyms:
Primolut Depot; HYDROXYPROGESTERONE CAPROATE; [(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] hexanoate;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
More recently has received the most attention in the prevention of preterm birth.
Quality Standard:
Enterprise Standard/USP
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Melting Point:
119-121 °C
InChIKey:
DOMWKUIIPQCAJU-LJHIYBGHSA-N
InChI:
1S/C27H40O4/c1-5-6-7-8-24(30)31-27(18(2)28)16-13-23-21-10-9-19-17-20(29)11-14-25(19,3)22(21)12-15-26(23,27)4/h17,21-23H,5-16H2,1-4H3/t21-,22+,23+,25+,26+,27+/m1/s1
Canonical SMILES:
CCCCCC(=O)OC1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)C(=O)C
Current Developer:
Squibb
1.Prevention of preterm delivery with compounded 17a-hydroxyprogesterone caproate.
Reed-Kane D Pharmd Fiacp Faca Fc1, Kirschbaum K Phd. Int J Pharm Compd. 2006 May-Jun;10(3):165-71.
17a-hydroxyprogesterone caproate is a naturally occurring metabolite of progesterone that is produced in significant quantities during pregnancy. The demand for 17a-hydroxyprogesterone caproate, the lack of a commercially available manufactured form approved by the US Food And Drug Administration, and publication of the results of a large trial to determine the effectivenss of the drug in the prevention of preterm delivery have spawned an increased interest in compounded formulations of the drug. The demand also has necessitated a review of the available literature and of past clinical studies, and a look at present and planned studies. Owing to the importance of this drug in pregnancy and the need for safety, accuracy in potency, and sterility in an intramuscular injection (the most common route of administration), compounding pharmacies must be in compliance with the United States Pharmacopeia Chapter 797 standards should they wish to compound this formulation.
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CAS 630-56-8 17α-Hydroxyprogesterone Caproate

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