17-AG - CAS 64202-81-9
Catalog number: 64202-81-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C28H39N3O8
Molecular Weight:
545.62
COA:
Inquire
Targets:
Hsp90
Description:
An orally bioavailable formulation of the ansamycin derivative 17-amino-17-demethoxygeldanamycin (17-AG) with potential antineoplastic activity. Oral Hsp90 inhibitor IPI-493 binds to and inhibits Hsp90, which may result the in growth inhibition in sensitive tumor cell populations.
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Brife Description:
IPI-493 is a potent and orally bioavailable Hsp90 inhibitor with Ki of 21 nM.
Purity:
>98%
Appearance:
Solid powder
Synonyms:
IPI493; IPI 493; NSC 255109; 17-Aminogeldanamycin; 17-Amino Geldanamycin; 17-Aminodemethoxygeldanamycin; 17-Amino-17-demethoxygeldanamycin
Solubility:
DMSO
Storage:
at -20°C 2 years
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
InChIKey:
XYFFWTYOFPSZRM-UWERUXQTSA-N
InChI:
InChI=1S/C28H39N3O8/c1-14-10-18-23(29)20(32)13-19(25(18)34)31-27(35)15(2)8-7-9-21(37-5)26(39-28(30)36)17(4)12-16(3)24(33)22(11-14)38-6/h7-9,12-14,16,21-22,24,26,33H,10-11,29H2,1-6H3,(H2,30,36)(H,31,35)/b9-7-,15-8+,17-12+/t14-,16+,21+,22+,24-,26+/m1/s1/i28+1,29+1
Canonical SMILES:
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)N)C)OC)OC(=O)N)C)C)O)OC
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CAS 64202-81-9 17-AG

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