1400W dihydrochloride - CAS 214358-33-5
Catalog number: 214358-33-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C10H17Cl2N3
Molecular Weight:
250.167
COA:
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Targets:
Nitric oxide synthase (NOS)
Description:
1400W is a selective inducible nitric oxide synthase (NOS) inhibitor(Ki=7nM).By suppressing the induction of inducible NOS, 1400W exhibits an therapeutical effect on ischemia reperfusion injury,acute hypobaric hypoxia/reoxygenation-induced cognitive deficits and tumor.
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Brife Description:
iNOS inhibitor,Nitric oxide synthase (NOS),ischemia reperfusion injury,acute hypobaric hypoxia,tumor
Purity:
>98%
Related CAS:
180001-34-7 (Free base)
Appearance:
Solid powder
Synonyms:
N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide, dihydrochloride; 1400W HCl; 1400W hydrochloride; 1400W (hydrochloride)
Solubility:
Soluble to 100 mM in water
Storage:
Store in a cool and dry place and at0-4℃ for short term(days to weeks)or -66℃ for long term(months to years).
MSDS:
Inquire
Application:
A selective inducible nitric oxide synthase (iNOS) inhibitor which has the potential for treatment of ischemia reperfusion injury,acute hypobaric hypoxia and tumor.
Shelf Life:
2 years
Boiling Point:
329ºC at 760 mmHg
InChIKey:
WDJHSQZCZGPGAA-UHFFFAOYSA-N
InChI:
1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
Canonical SMILES:
CC(NCC1=CC=CC(CN)=C1)=N.[H]Cl.[H]Cl
1.Optimization of cell-based assays to quantify the anti-inflammatory/allergic potential of test substances in 96-well format.
Chandrasekaran CV1, Edwin Jothie R, Kapoor P, Gupta A, Agarwal A. Inflammopharmacology. 2011 Jun;19(3):169-81. doi: 10.1007/s10787-010-0065-1. Epub 2010 Oct 31.
OBJECTIVE: There is an insistent need for robust, reliable, and optimized assays for screening novel drugs targeting the inflammatory/allergic markers. The present study describes about the optimization of eight cell-based assays utilizing mammalian cell lines in 96-well format for quantifying anti-inflammatory/allergic drug candidates.
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CAS 214358-33-5 1400W dihydrochloride

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