1400W dihydrochloride - CAS 214358-33-5
Catalog number: 214358-33-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Nitric oxide synthase (NOS)
1400W is a selective inducible nitric oxide synthase (NOS) inhibitor(Ki=7nM).By suppressing the induction of inducible NOS, 1400W exhibits an therapeutical effect on ischemia reperfusion injury,acute hypobaric hypoxia/reoxygenation-induced cognitive deficits and tumor.
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Brife Description:
iNOS inhibitor,Nitric oxide synthase (NOS),ischemia reperfusion injury,acute hypobaric hypoxia,tumor
Related CAS:
180001-34-7 (Free base)
Solid powder
N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide, dihydrochloride; 1400W HCl; 1400W hydrochloride; 1400W (hydrochloride)
Soluble to 100 mM in water
Store in a cool and dry place and at0-4℃ for short term(days to weeks)or -66℃ for long term(months to years).
A selective inducible nitric oxide synthase (iNOS) inhibitor which has the potential for treatment of ischemia reperfusion injury,acute hypobaric hypoxia and tumor.
Shelf Life:
2 years
Boiling Point:
329ºC at 760 mmHg
Canonical SMILES:
1.Optimization of cell-based assays to quantify the anti-inflammatory/allergic potential of test substances in 96-well format.
Chandrasekaran CV1, Edwin Jothie R, Kapoor P, Gupta A, Agarwal A. Inflammopharmacology. 2011 Jun;19(3):169-81. doi: 10.1007/s10787-010-0065-1. Epub 2010 Oct 31.
OBJECTIVE: There is an insistent need for robust, reliable, and optimized assays for screening novel drugs targeting the inflammatory/allergic markers. The present study describes about the optimization of eight cell-based assays utilizing mammalian cell lines in 96-well format for quantifying anti-inflammatory/allergic drug candidates.
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CAS 214358-33-5 1400W dihydrochloride

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