1400W - CAS 180001-34-7
Catalog number: 180001-34-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C10H15N3
Molecular Weight:
177.251
COA:
Inquire
Targets:
Nitric oxide synthase (NOS)
Description:
1400W is a selective inducible nitric oxide synthase (NOS) inhibitor(Ki=7nM,IC50=2.0uM).By suppressing the induction of inducible NOS, 1400W exhibits an therapeutical effect on ischemia reperfusion injury,acute hypobaric hypoxia/reoxygenation-induced cognitive deficits and tumor.
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Brife Description:
iNOS inhibitor,Nitric oxide synthase (NOS),ischemia reperfusion injury,acute hypobaric hypoxia,tumor
Purity:
>98%
Appearance:
White Solid
Synonyms:
N-[[3-(AMINOMETHYL)PHENYL]METHYL]-ETHANIMIDAMIDE DIHYDROCHLORIDE; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE 2HCL; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE, DIHYDROCHLORIDE
Storage:
Store in a cool and dry place and at0-4℃ for short term(days to weeks)or -66℃ for long term(months to years).
MSDS:
Inquire
Application:
A selective inducible nitric oxide synthase (iNOS) inhibitor. A long-acting human iNOS inhibitor possessing an IC50 value of 2.0uM.
Shelf Life:
2 years
InChIKey:
RODUKNYOEVZQPR-UHFFFAOYSA-N
InChI:
InChI=1S/C10H15N3/c1-8(12)13-7-10-4-2-3-9(5-10)6-11/h2-5H,6-7,11H2,1H3,(H2,12,13)
Canonical SMILES:
CC(=NCC1=CC(=CC=C1)CN)N
1.N-[3-(aminomethyl)benzyl]acetamidine (1400 W) as a potential immunomodulatory agent.
Mertas A1, Duliban H2, Szliszka E1, Machorowska-Pieniążek A3, Król W1. Oxid Med Cell Longev. 2014;2014:491214. doi: 10.1155/2014/491214. Epub 2014 Jun 5.
This study was designed to investigate the relationship between NO, IL-12, and TNF-α production by J774A.1 macrophages activated with LPS and IFN-γ in the presence of N-[3-(aminomethyl)benzyl]acetamidine (1400 W). 1400 W is a novel, highly selective inhibitor of inducible nitric oxide synthase (iNOS). We compared the obtained data with the effect of N(G)-monomethyl-L-arginine (L-NMMA) (a nonselective NOS inhibitor) and L-N(G)-(1-iminoethyl)lysine (L-NIL) (a relatively selective inhibitor of iNOS activity) on cells in this model. To investigate the involvement of an exogenous NO on IL-12 and TNF-α production we used NO donor-S-nitrosocaptopril (S-NO-Cap). The most potent inhibitor of NO generation was 1400 W. This compound also markedly increased IL-12 p40 secretion and decreased TNF-α release. L-NIL suppressed both NO and TNF-α production, but it did not change IL-12 p40 synthesis. The effect of L-NMMA on NO generation was weaker than other inhibitors.
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CAS 180001-34-7 1400W

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