1400W - CAS 180001-34-7
Catalog number: 180001-34-7
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C10H15N3
Molecular Weight:
177.251
COA:
Inquire
Targets:
Nitric oxide synthase (NOS)
Description:
1400W is a selective inducible nitric oxide synthase (NOS) inhibitor(Ki=7nM,IC50=2.0uM).By suppressing the induction of inducible NOS, 1400W exhibits an therapeutical effect on ischemia reperfusion injury,acute hypobaric hypoxia/reoxygenation-induced cognitive deficits and tumor.
Brife Description:
iNOS inhibitor,Nitric oxide synthase (NOS),ischemia reperfusion injury,acute hypobaric hypoxia,tumor
Purity:
>98%
Appearance:
White Solid
Synonyms:
N-[[3-(AMINOMETHYL)PHENYL]METHYL]-ETHANIMIDAMIDE DIHYDROCHLORIDE; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE 2HCL; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE, DIHYDROCHLORIDE
Storage:
Store in a cool and dry place and at0-4℃ for short term(days to weeks)or -66℃ for long term(months to years).
MSDS:
Inquire
Application:
A selective inducible nitric oxide synthase (iNOS) inhibitor. A long-acting human iNOS inhibitor possessing an IC50 value of 2.0uM.
Shelf Life:
2 years
InChIKey:
RODUKNYOEVZQPR-UHFFFAOYSA-N
InChI:
InChI=1S/C10H15N3/c1-8(12)13-7-10-4-2-3-9(5-10)6-11/h2-5H,6-7,11H2,1H3,(H2,12,13)
Canonical SMILES:
CC(=NCC1=CC(=CC=C1)CN)N
1.N-[3-(aminomethyl)benzyl]acetamidine (1400 W) as a potential immunomodulatory agent.
Mertas A1, Duliban H2, Szliszka E1, Machorowska-Pieniążek A3, Król W1. Oxid Med Cell Longev. 2014;2014:491214. doi: 10.1155/2014/491214. Epub 2014 Jun 5.
This study was designed to investigate the relationship between NO, IL-12, and TNF-α production by J774A.1 macrophages activated with LPS and IFN-γ in the presence of N-[3-(aminomethyl)benzyl]acetamidine (1400 W). 1400 W is a novel, highly selective inhibitor of inducible nitric oxide synthase (iNOS). We compared the obtained data with the effect of N(G)-monomethyl-L-arginine (L-NMMA) (a nonselective NOS inhibitor) and L-N(G)-(1-iminoethyl)lysine (L-NIL) (a relatively selective inhibitor of iNOS activity) on cells in this model. To investigate the involvement of an exogenous NO on IL-12 and TNF-α production we used NO donor-S-nitrosocaptopril (S-NO-Cap). The most potent inhibitor of NO generation was 1400 W. This compound also markedly increased IL-12 p40 secretion and decreased TNF-α release. L-NIL suppressed both NO and TNF-α production, but it did not change IL-12 p40 synthesis. The effect of L-NMMA on NO generation was weaker than other inhibitors.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Nitric oxide synthase (NOS) Products


Cindunistat hydrochloride maleate
(CAS: 753491-31-5)

Cindunistat is a selective Nitric oxide synthase (iNOS) type II inhibitor. It is potentially useful in patients with symptomatic osteoarthritis of the knee. But...

CAS 5154-02-9 1,5-Isoquinolinediol

1,5-Isoquinolinediol
(CAS: 5154-02-9)

1,5-Isoquinolinediol is a PARP1 inhibitor (IC50 value 0.39 - 1.00 μM) and neuroprotective agent leading to an increase up to 8-fold in the absolute frequency of...

CAS 25371-96-4 TRIM

TRIM
(CAS: 25371-96-4)

TRIM is a potent inhibitor of neuronal and inducible NO synthases (nNOS and iNOS), but exhibits lower affinity for the endothelial isoform (IC50 = 28.2, 27.0 an...

CAS 2219-31-0 L-Canavanine sulfate

L-Canavanine sulfate
(CAS: 2219-31-0)

The sulfate salt form of L-Canavanine, a homoserine analog, has been found to be a NO synthase inhibitor.

CAS 16011-96-4 2-Iminopiperidine hydrochloride

2-Iminopiperidine hydrochloride
(CAS: 16011-96-4)

2-Iminopiperidine hydrochloride is the hydrochloride salt of 2-Iminopiperidine, which is a potent inhibitor of human nitric oxide synthase isoform (iNOS). It is...

CAS 30344-00-4 SDMA

SDMA
(CAS: 30344-00-4)

An endogenous inhibitor of nitric oxide (NO) synthase activity

CAS 150403-89-7 L-NIL hydrochloride

L-NIL hydrochloride
(CAS: 150403-89-7)

L-NIL hydrochloride is a nitric oxide synthase inhibitor with IC50 value of 3.3 μM.

CAS 771-97-1 2,3-Diaminonaphthalene

2,3-Diaminonaphthalene
(CAS: 771-97-1)

2,3 Diaminonaphthalene is a highly selective colorimetric and fluorometric reagent for selenium detection and also an inhibitor of nitric oxide (NO) formation.

Chemical Structure

CAS 180001-34-7 1400W

Quick Inquiry

Verification code

Featured Items