|Targets||Nitric oxide synthase (NOS)|
|Description||1400W is a selective inducible nitric oxide synthase (NOS) inhibitor(Ki=7nM,IC50=2.0uM).By suppressing the induction of inducible NOS, 1400W exhibits an therapeutical effect on ischemia reperfusion injury,acute hypobaric hypoxia/reoxygenation-induced cognitive deficits and tumor.|
|Brife Description||iNOS inhibitor,Nitric oxide synthase (NOS),ischemia reperfusion injury,acute hypobaric hypoxia,tumor|
|Synonyms||N-[[3-(AMINOMETHYL)PHENYL]METHYL]-ETHANIMIDAMIDE DIHYDROCHLORIDE; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE 2HCL; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE, DIHYDROCHLORIDE|
|Storage||Store in a cool and dry place and at0-4℃ for short term(days to weeks)or -66℃ for long term(months to years).|
|Application||A selective inducible nitric oxide synthase (iNOS) inhibitor. A long-acting human iNOS inhibitor possessing an IC50 value of 2.0uM.|
|Shelf Life||2 years|
7-Nitroindazole is a nitric oxide synthase inhibitor.
GW 274150 is a potent, long-acting and highly selective inhibitor of iNOS which have a very high degree of selectivity for iNOS versus both eNOS (>100-fold) and...
L-NMMA is the archetypal competitive NOS inhibitor of all three NOS isoforms.
An endogenous inhibitor of nitric oxide (NO) synthase activity
The sulfate salt form of L-Canavanine, a homoserine analog, has been found to be a NO synthase inhibitor.
EIT hydrobromide is a potent and reversible inhibitor of isoform II NO synthase (IC50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III r...
L-NIO dihydrochloride is a nitric oxide synthase inhibitor. It can inhibit iNOS, eNOS and nNOS. Active in vivo.
7-NINA is a non-selective NOS inhibitor.
1,5-Isoquinolinediol is a PARP1 inhibitor (IC50 value 0.39 - 1.00 μM) and neuroprotective agent leading to an increase up to 8-fold in the absolute frequency of...
L-NIL hydrochloride is a nitric oxide synthase inhibitor with IC50 value of 3.3 μM.
FK-330 is a novel inducible nitric oxide synthase inhibitor for preventing ischemia and reperfusion injury in rat liver transplantation.
2-Iminopiperidine hydrochloride is the hydrochloride salt of 2-Iminopiperidine, which is a potent inhibitor of human nitric oxide synthase isoform (iNOS). It is...
BYK 191023 dihydrochloride
BYK 191023 dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS) (IC50 = 86, 17000, 162000 nM for iNOS, nNOS and eNOS, r...
Agmatine sulfate, the sulfate preparation of Agmatine, is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. Agmatine displaces clonidin...
Nω-Propyl-L-arginine hydrochloride is a neuronal selective nitric oxide synthase inhibitor and a potent and selective inhibitor of NOS1 (nNOS) (Ki = 57 nM) with...
(S)-Methylisothiourea sulfate is a more potent than NMMA as an inhibitor of inducible nitric oxide synthetase (iNOS). The Ki values are 120, 200, and 160 nM usi...
2,4-Diamino-6-hydroxypyrimidine has been found to be a GCH1 inhibitor and could suppress the activity of NO synthase through preventing the synthesis of BH4.
1400W is a selective inducible nitric oxide synthase (NOS) inhibitor(Ki=7nM,IC50=2.0uM).By suppressing the induction of inducible NOS, 1400W exhibits an therape...
TRIM is a potent inhibitor of neuronal and inducible NO synthases (nNOS and iNOS), but exhibits lower affinity for the endothelial isoform (IC50 = 28.2, 27.0 an...
The dihydrobromide salt form of 1,4-PB-ITU, a carbamimidoylsulfanyl derivative, has been found to be an iNOS and nNOS inhibitor that has poor membrane permeabil...