11(13)-Dehydroivaxillin - CAS 87441-73-4
Catalog number: 87441-73-4
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Molecular Formula:
C15H20O4
Molecular Weight:
264.3
COA:
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Chemical Family:
Sesquiterpenoids
Description:
11(13)-Dehydroivaxillin, that can be found in the herbs of Carpesium abrotanoides L, possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.
Purity:
>98%
Appearance:
Powder
Synonyms:
11,13-Dehydroeriolin
MSDS:
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Application:
Anti-plasmodial
Quality Standard:
Enterprise Standard
Quantity:
Milligrams-Grams
1.In vivo antiplasmodial activity of 11(13)-dehydroivaxillin from Carpesium ceruum.
Kim JJ;Chung IM;Jung JC;Kim MY;Moon HI J Enzyme Inhib Med Chem. 2009 Feb;24(1):247-50. doi: 10.1080/14756360802051610 .
The whole plants of Carpesium genus are used in traditional medicine as anti-pyretic, analgesic and vermifugic, including a topical application for sores and inflammation. A previous study on Carpesium genus suggested that the antiplasmodial activity against Plasmodium falciparum was due to the existence of 11(13)- dehydroivaxillin (DDV) from EtOAc extracts of C. ceruum (Compositae). Here, the antimalarial activity of DDV was evaluated against Plasmodium berghei in mice. The LD(50) of the compound was determined as 51.2 mg/kg, while doses of 124 mg/kg and above were found to be lethal to mice. DDV (2, 5, 10 mg/kg/day) exhibited a significant blood schizontocidal activity in 4-day early infection, repository evaluation and in an established infection with a significant mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day. DDV possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.
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CAS 87441-73-4 11(13)-Dehydroivaxillin

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