11,12-Di-O-acetyltenacigenin B - CAS 857897-01-9
Catalog number: 857897-01-9
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11,12-Di-O-acetyltenacigenin B is a natural steroid found in the herbs of Marsdenia tenacissima.
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1.Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency.
Al-Herz W1, Chu JI2, van der Spek J3, Raghupathy R4, Massaad MJ5, Keles S5, Biggs CM5, Cockerton L6, Chou J5, Dbaibo G7, Elisofon SA8, Hanna-Wakim R7, Kim HB9, Lehmann LE2, McDonald DR5, Notarangelo LD5, Veys P6, Chatila TA5, Geha RS5, Gaspar HB10, Pai SY11. J Allergy Clin Immunol. 2016 Apr 6. pii: S0091-6749(16)30010-0. doi: 10.1016/j.jaci.2016.02.022. [Epub ahead of print]
BACKGROUND: Dedicator of cytokinesis 8 (DOCK8) deficiency can be cured by allogeneic hematopoietic stem cell transplantation (HSCT). Reports of outcomes are still limited.
2.Role of the tumor microenvironment in mature B-cell lymphoid malignancies.
Fowler NH1, Cheah CY2, Gascoyne RD3, Gribben J4, Neelapu SS5, Ghia P6, Bollard C7, Ansell S8, Curran M5, Wilson WH9, O'Brien S10, Grant C11, Little R12, Zenz T13, Nastoupil LJ5, Dunleavy K9. Haematologica. 2016 May;101(5):531-540.
The tumor microenvironment is the cellular and molecular environment in which the tumor exists and with which it continuously interacts. In B-cell lymphomas, this microenvironment is intriguing in that it plays critical roles in the regulation of tumor cell survival and proliferation, fostering immune escape as well as the development of treatment resistance. The purpose of this review is to summarize the proceedings of the Second Annual Summit on the Immune Microenvironment in Hematologic Malignancies that took place on September 11-12, 2014 in Dublin, Ireland. We provide a timely overview of the composition and biological relevance of the cellular and molecular microenvironment interface and discuss the role of interactions between the microenvironment and neoplastic cells in a variety of B-cell lymphomas. In addition, we focus on various novel therapeutic strategies that target the tumor microenvironment, including agents that modulate B-cell receptor pathways and immune-checkpoints, chimeric antigen receptor T cells and immunomodulatory agents.
3.Prognostic Role of Pre-Radiation Therapy 18F-Fluorodeoxyglucose Positron Emission Tomography for Primary Mediastinal B-Cell Lymphomas Treated with R-CHOP or R-CHOP-Like Chemotherapy Plus Radiation.
Filippi AR1, Piva C2, Levis M2, Chiappella A3, Caracciolo D4, Bellò M5, Bisi G6, Vitolo U3, Ricardi U2. Int J Radiat Oncol Biol Phys. 2016 Mar 2. pii: S0360-3016(16)00226-1. doi: 10.1016/j.ijrobp.2016.02.057. [Epub ahead of print]
PURPOSE: To validate, in a monoinstitutional cohort with extended follow-up, that post-rituximab chemotherapy (R-CT) 18F-fluorodeoxyglucose positron emission tomography (18FDG-PET) is a prognostic factor allowing discrimination of primary mediastinal B-cell lymphoma (PMBCL) patients at higher risk for progression after radiation therapy.
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CAS 857897-01-9 11,12-Di-O-acetyltenacigenin B

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