10Z-Hymenialdisine - CAS 82005-12-7
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
10Z-Hymenialdisine is a pan kinase inhibitor (IC50 values are 6, 10, 22, 28, 35, 40, 70, 80, 100, 470, 500, 600, 700 and 700 nM for MEK1, GSK-3β, Cdk1/cyclin B, Cdk5/p25, CK1, Cdk2/cyclin A, Cdk2/cyclin E, ASK-γ, Cdk3/cyclin E, Erk1, PKCγ, Cdk4/cyclin D1, Cdk6/cyclin D2 and PKCα, respectively). 10Z-Hymenialdisine inhibits NF-κB activation and suppresses inflammatory gene expression.
Brife Description:
kinase inhibitor
≥97% by HPLC
Canonical SMILES:
1.Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).
Tasdemir D;Mallon R;Greenstein M;Feldberg LR;Kim SC;Collins K;Wojciechowicz D;Mangalindan GC;Concepción GP;Harper MK;Ireland CM J Med Chem. 2002 Jan 17;45(2):529-32.
Raf/MEK-1/MAPK cascade inhibitor activity-directed fractionation of the sponge Stylissa massa afforded eight known alkaloids: aldisine (1), 2-bromoaldisine (2), 10Z-debromohymenialdisine (3), 10E-hymenialdisine (4), 10Z-hymenialdisine (5), hymenin (6), oroidin (7), and 4,5-dibromopyrrole-2-carbonamide (8). Both 4 and 5 showed significant enzyme inhibitory activity (IC(50) 3 and 6 nM, respectively). Secondary assays identified these compounds as potent MEK-1 inhibitors. Compounds 4 and 5 also inhibited the growth of human tumor LoVo cells.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

CAS 857064-38-1 WP1066

(CAS: 857064-38-1)

WP1066 is a Stat3 inhibitor and JAK2 inhibitor. WP1066 is also a novel analogue of the JAK2 inhibitor AG490, in JAK2 V617F-positive erythroleukemia HEL cells a...

CAS 1357389-11-7 RGFP966

(CAS: 1357389-11-7)

RGFP966 is a selective HDAC3 inhibitor. Systemic treatment with RGFP966 facilitates extinction in mice in a manner resistant to reinstatement. A single treatmen...

CAS 3232-36-8 SCS

(CAS: 3232-36-8)

SCS is a potent and selective partial inhibitor of β1-containing GABAA receptors (IC50 = 4.5, 5.3 and 7.9 nM at α2β1γ1θ, α2β1γ1 and α2β1γ2s GABAA receptors, res...

CAS 781613-23-8 XL-647

(CAS: 781613-23-8)

XL647 is an orally bioavailable small-molecule receptor tyrosine kinase inhibitor with potential antineoplastic activity. It inhibits EGFR, HER2, VEGFR and EphB...

CAS 603288-22-8 LY2090314

(CAS: 603288-22-8)

LY2090314  is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) which plays an important role in many pathways, including initiation of protein synthesis...

CAS 749269-83-8 CHF 5074

CHF 5074
(CAS: 749269-83-8)

CHF5074, also known as CSP-1103, is a novel γ-secretase modulator. It could reduce Aβ42 and Aβ40 secretion, which IC50 value is 3.6 and 18.4 μM respectively. It...

CAS 2060530-16-5 MDK30165

(CAS: 2060530-16-5)

MDK30165, also known as K-Ras(G12C) Inhibitor 6, is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein...

CAS 63238-67-5 Benzoylmesaconine

(CAS: 63238-67-5)

Benzoylmesaconine is the most abundant component of Wutou decoction, which is widely used in China because of its therapeutic effect on rheumatoid arthritis.

Chemical Structure

CAS 82005-12-7 10Z-Hymenialdisine

Quick Inquiry

Verification code

Featured Items