10-methylacridin-10-ium-9-amine bromide - CAS 64046-88-4
Catalog number: 64046-88-4
Category: Main Product
Molecular Formula:
Molecular Weight:
289.17 g/mol
1.Pharmacokinetics of aclidinium bromide/formoterol fumarate fixed-dose combination compared with individual components: A phase 1, open-label, single-dose study.
Fuhr R1, Leselbaum A2, Aubets J3. Clin Pharmacol Drug Dev. 2016 Mar;5(2):109-17. doi: 10.1002/cpdd.209. Epub 2015 Aug 24.
Inhaled, long-acting bronchodilators represent a cornerstone of maintenance treatment for chronic obstructive pulmonary disease (COPD). Aclidinium bromide/formoterol fumarate 400/12 μg fixed-dose combination (FDC) has recently been licensed for use in adults with COPD in the European Union. This phase 1, randomized, open-label, 3-way, complete crossover, single-dose study assessed the pharmacokinetics, safety, and tolerability of an FDC, aclidinium bromide 400 μg, and formoterol fumarate 12 μg, all administered via Genuair™ to 30 healthy subjects. The rate and extent of absorption were comparable for aclidinium/formoterol FDC and individual monotherapies; aclidinium/formoterol FDC and aclidinium alone: Cmax , 270 and 215 pg/mL, respectively; AUC0-t , 229 and 222 pg · h/mL, respectively; aclidinium/formoterol FDC and formoterol alone: Cmax , 11 and 9.3 pg/mL, respectively; AUC, 36 and 32.4 pg · h/mL, respectively. There were no major differences in relative bioavailability between the combination and monotherapies: the aclidinium Cmax and AUC0-t were 26% and 3% higher, respectively, with aclidinium/formoterol FDC compared with aclidinium alone, and 18% and 11% higher, respectively, compared with formoterol alone.
2.Photoredox-Catalyzed Bromodifluoromethylation of Alkenes with (Difluoromethyl)triphenylphosphonium Bromide.
Lin QY1, Ran Y1, Xu XH1, Qing FL1,2. Org Lett. 2016 May 3. [Epub ahead of print]
Under visible-light photoredox conditions, difluoromethyltriphenylphosphonium bromide was used as the precursor of the CF2H radical for bromodifluoromethylation of alkenes. The presence of catalytic CuBr2 resulted in the selective formation of the bromodifluoromethylated products.
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CAS 64046-88-4 10-methylacridin-10-ium-9-amine bromide

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