10-Deacetylbaccatin-III - CAS 32981-86-5
Catalog number:
32981-86-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C29H36O10
Molecular Weight:
544.59
COA:
Inquire
Targets:
Others
Description:
10-Deacetylbaccatin-III is an antineoplastic agent and an anti-cancer intermediate.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
MSDS:
Inquire
1.Organocatalytic Site-Selective Acylation of 10-Deacetylbaccatin III.
Yanagi M1, Ninomiya R, Ueda Y, Furuta T, Yamada T, Sunazuka T, Kawabata T. Chem Pharm Bull (Tokyo). 2016 Feb 23. [Epub ahead of print]
Organocatalytic site-selective diversification of 10-deacetylbaccatin III, a key natural product for the semisynthesis of taxol, has been achieved. Various acyl groups were selectively introduced into the C(10)-OH of 10-deacetylbaccatin III. The C(10)-OH selective acylation was also applied to acylative site-selective dimerization of 10-deacetylbaccatin III to provide the structurally defined dimer.
2.Simultaneous determination of seven taxoids in rat plasma by UPLC-MS/MS and pharmacokinetic study after oral administration of Taxus yunnanensis extracts.
Liu B1, Gou X1, Bai X1, Hou X1, Li D1, Zhong G1, Jin J2, Huang M3. J Pharm Biomed Anal. 2015 Mar 25;107:346-54. doi: 10.1016/j.jpba.2015.01.001. Epub 2015 Jan 10.
A rapid, sensitive and reliable method has been developed and validated for the simultaneous determination of seven taxoids including 10-deacetylbaccatin III (10-DAB III), baccatin III, 5-epi-canadensene, taxinine M, 10-deacetyltaxol (10-DAT), cephalomannine and paclitaxel in rat plasma using docetaxel as the internal standard (IS). The plasma samples were pretreated by liquid-liquid extraction with methyl tert-butyl ether. The chromatographic separation was achieved on a C18 column (50 mm × 2.1 mm, 1.8 μm, Waters, USA) with a gradient elution program consisting of methanol and water (containing 0.1% formic acid) at a flow rate of 0.2 mL/min. Detection was performed under the selected reaction monitoring (SRM) scan using an electrospray ionization (ESI) in the positive ion mode. The mass transitions were as follows: m/z 567.4→444.9 for 10-DAB III, m/z 609.0→549.3 for baccatin III, m/z 617.4→496.9 for 5-epi-canadensene, m/z 709.6→649.3 for taxinine M, m/z 834.
3.Organocatalytic Site-Selective Acylation of 10-Deacetylbaccatin III.
Yanagi M1, Ninomiya R, Ueda Y, Furuta T, Yamada T, Sunazuka T, Kawabata T. Chem Pharm Bull (Tokyo). 2016 Feb 23. [Epub ahead of print]
Organocatalytic site-selective diversification of 10-deacetylbaccatin III, a key natural product for the semisynthesis of taxol, has been achieved. Various acyl groups were selectively introduced into the C(10)-OH of 10-deacetylbaccatin III. The C(10)-OH selective acylation was also applied to acylative site-selective dimerization of 10-deacetylbaccatin III to provide the structurally defined dimer.
4.[Extraction of 10-Deacetyl Baccatin by Supercritical CO2 from Taxus yunnanensis Branches and Leaves].
Tang YQ, Li HC, Huang WJ, Xiong Y, Ge FH. Zhong Yao Cai. 2015 Apr;38(4):827-30.
OBJECTIVE: To study the supercritical CO2 fluids extraction (SFE) method to extract the components from Taxus yunnanensis.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 6880-91-7 Dihydrochelerythrine

Dihydrochelerythrine
(CAS: 6880-91-7)

Dihydrochelerythrine is a natural compound isolated from the leaves of Macleaya microcarpa, which has antifungal activity.

CAS 199666-03-0 Ro 61-8048

Ro 61-8048
(CAS: 199666-03-0)

Potent and competitive kynurenine 3-hydroxylase inhibitor (IC50 = 37 nM). Shows antidystonic, anticonvulsant and neuroprotective effects in vivo. Blood-brain ba...

FR-193262
(CAS: 187992-22-9)

FR-193262 is a designed prostacyclin mimetic without PG skeleton which exhibits potent PGI2 agonistic activity with good selectivity for IP receptor and bioavai...

CAS 141625-93-6 Dronedarone  HCl

Dronedarone HCl
(CAS: 141625-93-6)

Dronedarone HCl is a therapy for the treatment of patients with paroxysmal and persistent atrial fibrillation or atrial flutter.

LY-113174
(CAS: 112959-07-6)

LY-113174 is a novel class of nonsteroidal aromatase inhibitor. It may prove useful in the treatment of estrogen-dependent diseases.

CAS 130-95-0 Quinine

Quinine
(CAS: 130-95-0)

Quinine is a primary alkaloid of various species of Cinchona. Because of its relatively constant and well-known fluorescence quantum yield, quinine is also used...

V5 Epitope Tag Peptide

V5 Epitope Tag Peptide, a tag peptide derived from a small epitope present on the P and V proteins of the paramyxovirus of simian virus 5, is used as a blocking...

MK-3328
(CAS: 1201323-97-8)

This molecular has a favorable potency versus human β-amyloid plaque and has been radiolabeled for further evaluation in in vitro binding and in vivo PET imagin...

CAS 124190-19-8 FR 901235

FR 901235
(CAS: 124190-19-8)

This active molecular is an immunoactive substance that produced by Paecilomyces carneus F-4882, an imperfect fungus. FR-901235 can lead to the mitogen-induced ...

CAS 69207-52-9 McN3716

McN3716
(CAS: 69207-52-9)

An inhibitor of carnitine palmitoyltransferase I (CPT-1)

CAS 1216897-16-3 2-(5-fluoropentyl)-2-methylmalonic acid

2-(5-fluoropentyl)-2-methylmalonic acid
(CAS: 1216897-16-3)

This molecular is a [18F] PET (positron emission tomography) radiotracer. It can accumulate in cells presenting apoptosis-specific membrane alterations. ML-10 a...

CAS 123-99-9 1,7-Heptanedicarboxylic Acid

1,7-Heptanedicarboxylic Acid
(CAS: 123-99-9)

Azelaic acid, produced by ozone cracking of unsaturated fatty acid, could be commonly used in grease, cosmetics and pharmaceuticals.

CAS 107534-93-0 Macelignan

Macelignan
(CAS: 107534-93-0)

Macelignan is a natural compound isolated from Myristica fragrans Houtt. It possesses therapeutic potentials against neurodegenerative diseases with oxidative s...

CAS 189197-69-1 Ro 48-8071 fumarate

Ro 48-8071 fumarate
(CAS: 189197-69-1)

Ro 48-8071 is an orally active cholesterol synthesis inhibitor or a 2,3-oxidosqualene:lanosterol cyclase (OSC) inhibitor. OSC (EC 5.4.99.7) represents a unique ...

CI 924
(CAS: 79520-77-7)

CI 924 is hypolipidemic agent. It can elevate anti-atherogenic HDL and lower VLDL.

NCT-501
(CAS: 1802088-50-1)

NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.

PYR-6921
(CAS: 31896-92-1)

PYR-6921is a useful intermediate for chemical synthesis of biologically molecules.

CAS 2447-54-3 Sanguinarine

Sanguinarine
(CAS: 2447-54-3)

Sanguinarine caused cell death in a dose dependent manner in all neuroblastoma cell lines except SK-N-BE(2) with rates of 18% in SH-SY5Y and 21% in Kelly human ...

CAS 195514-80-8 AP20187

AP20187
(CAS: 195514-80-8)

Systemic AP20187 administration results in time-dependent LFv2IRE tyrosine phosphorylation and activation of the insulin signaling pathway in both liver and mus...

CAS 591778-70-0 CP640186 HCl

CP640186 HCl
(CAS: 591778-70-0)

CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respec...

Chemical Structure

CAS 32981-86-5 10-Deacetylbaccatin-III

Quick Inquiry

Verification code

Featured Items