10-Deacetylbaccatin-III - CAS 32981-86-5
Catalog number: 32981-86-5
Category: Inhibitor
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Molecular Formula:
C29H36O10
Molecular Weight:
544.59
COA:
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Targets:
Others
Description:
10-Deacetylbaccatin-III is an antineoplastic agent and an anti-cancer intermediate.
Purity:
>98%
Synonyms:
10DAB; 10DAB III; 10Deacetylbaccatin III. 10deacetyl baccatin III
MSDS:
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InChIKey:
YWLXLRUDGLRYDR-ZHPRIASZSA-N
InChI:
InChI=1S/C29H36O10/c1-14-17(31)12-29(36)24(38-25(35)16-9-7-6-8-10-16)22-27(5,23(34)21(33)20(14)26(29,3)4)18(32)11-19-28(22,13-37-19)39-15(2)30/h6-10,17-19,21-22,24,31-33,36H,11-13H2,1-5H3/t17-,18-,19+,21+,22-,24-,27+,28-,29+/m0/s1
Canonical SMILES:
CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1O)O)OC(=O)C5=CC=CC=C5)(CO4)OC(=O)C)O)C)O
1.Organocatalytic Site-Selective Acylation of 10-Deacetylbaccatin III.
Yanagi M1, Ninomiya R, Ueda Y, Furuta T, Yamada T, Sunazuka T, Kawabata T. Chem Pharm Bull (Tokyo). 2016 Feb 23. [Epub ahead of print]
Organocatalytic site-selective diversification of 10-deacetylbaccatin III, a key natural product for the semisynthesis of taxol, has been achieved. Various acyl groups were selectively introduced into the C(10)-OH of 10-deacetylbaccatin III. The C(10)-OH selective acylation was also applied to acylative site-selective dimerization of 10-deacetylbaccatin III to provide the structurally defined dimer.
2.Simultaneous determination of seven taxoids in rat plasma by UPLC-MS/MS and pharmacokinetic study after oral administration of Taxus yunnanensis extracts.
Liu B1, Gou X1, Bai X1, Hou X1, Li D1, Zhong G1, Jin J2, Huang M3. J Pharm Biomed Anal. 2015 Mar 25;107:346-54. doi: 10.1016/j.jpba.2015.01.001. Epub 2015 Jan 10.
A rapid, sensitive and reliable method has been developed and validated for the simultaneous determination of seven taxoids including 10-deacetylbaccatin III (10-DAB III), baccatin III, 5-epi-canadensene, taxinine M, 10-deacetyltaxol (10-DAT), cephalomannine and paclitaxel in rat plasma using docetaxel as the internal standard (IS). The plasma samples were pretreated by liquid-liquid extraction with methyl tert-butyl ether. The chromatographic separation was achieved on a C18 column (50 mm × 2.1 mm, 1.8 μm, Waters, USA) with a gradient elution program consisting of methanol and water (containing 0.1% formic acid) at a flow rate of 0.2 mL/min. Detection was performed under the selected reaction monitoring (SRM) scan using an electrospray ionization (ESI) in the positive ion mode. The mass transitions were as follows: m/z 567.4→444.9 for 10-DAB III, m/z 609.0→549.3 for baccatin III, m/z 617.4→496.9 for 5-epi-canadensene, m/z 709.6→649.3 for taxinine M, m/z 834.
3.Organocatalytic Site-Selective Acylation of 10-Deacetylbaccatin III.
Yanagi M1, Ninomiya R, Ueda Y, Furuta T, Yamada T, Sunazuka T, Kawabata T. Chem Pharm Bull (Tokyo). 2016 Feb 23. [Epub ahead of print]
Organocatalytic site-selective diversification of 10-deacetylbaccatin III, a key natural product for the semisynthesis of taxol, has been achieved. Various acyl groups were selectively introduced into the C(10)-OH of 10-deacetylbaccatin III. The C(10)-OH selective acylation was also applied to acylative site-selective dimerization of 10-deacetylbaccatin III to provide the structurally defined dimer.
4.[Extraction of 10-Deacetyl Baccatin by Supercritical CO2 from Taxus yunnanensis Branches and Leaves].
Tang YQ, Li HC, Huang WJ, Xiong Y, Ge FH. Zhong Yao Cai. 2015 Apr;38(4):827-30.
OBJECTIVE: To study the supercritical CO2 fluids extraction (SFE) method to extract the components from Taxus yunnanensis.
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CAS 32981-86-5 10-Deacetylbaccatin-III

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