|Description||10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility. It induced mitotic cell cycle arrest and apoptosis as measured by flow cytometry, DNA laddering, and transmission electron microscopy. Moreover, it had no effect on the expression of CD95 and NF-kappaB proteins, indicating that apoptosis was induced through the mitochondrial-dependent pathway in PC-3 cells.|
|Synonyms||10-Deacetyl-7-xylosyltaxol; 10-Deacetylpaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside|
DCEBIO is a Ca2+ sensitive K+ channel (SKCa) agonist stimulating Cl- secretion via activation of hKCa3.1 (IK1) potassium channels and activation of an apical Cl...
TG 4-155 is a high affinity and selective EP2 receptor antagonist (KB = 2.4 and 34.5 nM for EP2 and DP1 receptors, respectively) displaying >500-fold selectivit...
Clazosentan, also called as AXV 034, Ro 61-1790 or VML 588, a novel endothelin A antagonist, improves cerebral blood flow and behavior after traumatic brain inj...
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IRL-1620, also known as SPI-1620, is an endothelin B receptor agonist. SPI-1620 is a highly selective peptide agonist of the endothelin-B receptor. Endothelin...
Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor.
Nortriptyline is a second-generation antidepressant originated by Lilly. It is a non-selective monoamine reuptake inhibitor. Nortriptyline can be used for the t...
Mirodenafil is a newly developed oral phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. It significantly improved ...