1.NitroMAC: An instrument for the measurement of HONO and intercomparison with a long-path absorption photometer.
Afif C1, Jambert C2, Michoud V2, Colomb A2, Eyglunent G3, Borbon A2, Daële V3, Doussin JF2, Perros P2. J Environ Sci (China). 2016 Feb;40:105-13. doi: 10.1016/j.jes.2015.10.024. Epub 2016 Jan 11.
NitroMAC (French acronym for continuous atmospheric measurements of nitrogenous compounds) is an instrument which has been developed for the semi-continuous measurement of atmospheric nitrous acid (HONO). This instrument relies on wet chemical sampling and detection using high performance liquid chromatography (HPLC)-visible absorption at 540nm. Sampling proceeds by dissolution of gaseous HONO in a phosphate buffer solution followed by derivatization with sulfanilamide/N-(1-naphthyl)-ethylenediamine. The performance of this instrument was found to be as follows: a detection limit of around 3ppt with measurement uncertainty of 10% over an analysis time of 10min. Intercomparison was made between the instrument and a long-path absorption photometer (LOPAP) during two experiments in different environments. First, air was sampled in a smog chamber with concentrations up to 18ppb of nitrous acid. NitroMAC and LOPAP measurements showed very good agreement.
2.Alleviation of cyclophosphamide-induced immunosuppression in Wistar rats by onion lectin (Allium cepa agglutinin).
Kumar VP1, Venkatesh YP2. J Ethnopharmacol. 2016 Apr 5. pii: S0378-8741(16)30197-0. doi: 10.1016/j.jep.2016.04.006. [Epub ahead of print]
ETHNOPHARMACOLOGICAL RELEVANCE: In various traditional medicines, onion has been classified as an immune-boosting food. Recent studies have claimed this property due to the presence of bioactive organosulfur compounds, prebiotic fructo-oligosaccharides and an immunomodulatory protein, lectin (Allium cepa agglutinin; ACA) (Prasanna, V.K., Venkatesh, Y.P., 2015. Characterization of onion lectin (Allium cepa agglutinin) as an immunomodulatory protein inducing Th1-type immune response in vitro. Int. Immunopharmacol. 26, 304-313).
3.Synthesis of 2-arylfuro[3,2-b]pyridines: Effect of the C2-aryl group on melatoninergic activity.
Couhert A1, Delagrange P2, Caignard DH2, Chartier A1, Suzenet F3, Guillaumet G4. Eur J Med Chem. 2016 Feb 15;109:268-75. doi: 10.1016/j.ejmech.2016.01.008. Epub 2016 Jan 12.
We report herein an efficient synthesis of 2-substituted furo[3,2-b]pyridines and their biological evaluation as melatonin receptors ligands. The proposed eight-step sequence ending with a Suzuki coupling allowed a rapid access to various analogues. The steric hindrance and the conformation of the aryl group in C2-position were evaluated regarding the selectivity of the molecule for one of the two high affinity melatonin receptors as well as the activity profile of the compound. Introduction of 1-naphthyl substituent gave the best result in terms of selectivity with a MT1/MT2 ratio of about 150 (MT1 Ki = 198 nM, MT2 Ki = 1.3 nM).
4.Red Phosphorescent Bis-Cyclometalated Iridium Complexes with Fluorine-, Phenyl-, and Fluorophenyl-Substituted 2-Arylquinoline Ligands.
Kim J1, Lee KH1, Lee SJ2, Lee HW2, Kim YK3, Kim YS4, Yoon SS5. Chemistry. 2016 Mar 14;22(12):4036-45. doi: 10.1002/chem.201504392. Epub 2016 Feb 16.
Red phosphorescent iridium(III) complexes based on fluorine-, phenyl-, and fluorophenyl-substituted 2-arylquinoline ligands were designed and synthesized. To investigate their electrophosphorescent properties, devices were fabricated with the following structure: indium tin oxide (ITO)/4,4',4''-tris[2-naphthyl(phenyl)amino]triphenylamine (2-TNATA)/4,4'-bis[N-(1-naphthyl)-N-phenylamino]biphenyl (NPB)/4,4'-bis(N-carbazolyl)-1,1'-biphenyl (CBP): 8 % iridium (III) complexes/bathocuproine (BCP)/tris(8-hydroxyquinolinato)aluminum (Alq3 )/8-hydroxyquinoline lithium (Liq)/Al. All devices, which use these materials showed efficient red emissions. In particular, a device exhibited a saturated red emission with a maximum luminance, external quantum efficiency, and luminous efficiency of 14200 cd m(-2) , 8.44 %, and 6.58 cd A(-1) at 20 mA cm(-2) , respectively. The CIE (x, y) coordinates of this device are (0.67, 0.33) at 12.0 V.