1,2-Dimyristoyl-rac-glycero-3-phospho-rac-(1-glycerol) sodium salt - CAS 67232-80-8
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1,2-Dimyristoyl-rac-glycero-3-phospho-rac-(1-glycerol) is a phosphatidylglycerol with myristic acid. Phosphatidylglycerol is a phospholipid found in pulmonary surfactant. It can be used in lipid-based drug delivery studies.
DMPG, Na; DMPG-Na; Sodium Dimyristoylphosphatidylglycerol
1.Extensive bilayer perforation coupled with the phase transition region of an anionic phospholipid.
Riske KA1, Amaral LQ, Lamy MT. Langmuir. 2009 Sep 1;25(17):10083-91. doi: 10.1021/la9012137.
At low ionic strength dimyristoylphosphatidylglycerol (DMPG) exhibits a broad phase transition region characterized by several superimposed calorimetric peaks. Peculiar properties, such as sample transparency, are observed only in the transition region. In this work we use differential scanning calorimetry (DSC), turbidity, and optical microscopy to study the narrowing of the transition region with the increase of ionic strength (0-500 mM NaCl). Upon addition of salt, the temperature extension of the transition region is reduced, and the number of calorimetric peaks decreases until a single cooperative event at T(m) = 23 degrees C is observed in the presence of 500 mM NaCl. The transition region is always coupled with a decrease in turbidity, but a transparent region is detected within the melting process only in the presence of up to 20 mM NaCl. The vanishing of the transparent region is associated with one of the calorimetric peaks. Optical microscopy of giant vesicles shows that bilayers first rupture when the transition region is reached and subsequently lose optical contrast.
2.Enhanced bactericidal potency of nanoliposomes by modification of the fusion activity between liposomes and bacterium.
Ma Y1, Wang Z, Zhao W, Lu T, Wang R, Mei Q, Chen T. Int J Nanomedicine. 2013;8:2351-60. doi: 10.2147/IJN.S42617. Epub 2013 Jun 28.
BACKGROUND: Pseudomonas aeruginosa represents a good model of antibiotic resistance. These organisms have an outer membrane with a low level of permeability to drugs that is often combined with multidrug efflux pumps, enzymatic inactivation of the drug, or alteration of its molecular target. The acute and growing problem of antibiotic resistance of Pseudomonas to conventional antibiotics made it imperative to develop new liposome formulations to overcome these mechanisms, and investigate the fusion between liposome and bacterium.
3.Interaction of piroxicam and meloxicam with DMPG/DMPC mixed vesicles: anomalous partitioning behavior.
Chakraborty H1, Sarkar M. Biophys Chem. 2007 Feb;125(2-3):306-13. Epub 2006 Sep 28.
Small unilamellar vesicles (SUVs) formed from a mixture of dimyristoylphosphatidylcholine (zwitterionic lipid with bulkier headgroup) and dimyristoylphosphatidylglycerol (anionic lipid with relatively smaller headgroup) allows better modulation of the physical properties of lipid bilayers compared to SUVs formed by a single type of lipid, providing us with a better model system to study the effect of membrane parameters on the partitioning of small molecules. Membrane parameter like packing of the vesicles is more pronounced in the gel phase and hence the study was carried out in the gel phase. Mixed vesicles formed from DMPG and DMPC with the mole percent ratio of 100:0, 90:10 and 80:20 were used for this study. As examples of polar solutes, piroxicam and meloxicam, two Non Steroidal Anti-inflammatory Drugs (NSAIDs) were chosen. The pH was adjusted to 2.8 in order to eliminate the presence of anionic forms of the drugs that would not approach the vesicles containing negatively charged DMPG (50% deprotonated at pH 2.
4.Phase dependent electrochemical properties of polar self-assembled monolayers (SAMs) modified via the fusion of mixed phospholipid vesicles.
Twardowski M1, Nuzzo RG. Langmuir. 2004 Jan 6;20(1):175-80.
Unilamellar vesicles of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and varying quantities of either 1,2-dimyristoyl-sn-glycero-3-[phospho-rac-(1-glycerol) (sodium salt) (DMPG) or 1,2-dimyristoyl-3-trimethylammonium-propane (chloride salt) (DMTAP) were used to deposit lipid bilayer assemblies on self-assembled monolayers (SAMs) on gold. The supporting SAMs in turn were composed of ferrocene-functionalized hexadecanethiol chains (FcC16SH) diluted to low coverage in 1-hydroxylhexadecanethiol (HOC16SH) or a single-component monolayer phase of the latter. The mass coverages of the DMPC/DMPG layers deposited in this way were measured using surface plasmon resonance (SPR) and found to decrease with an increasing content of DMPG in the vesicles. The SPR data show that the lipid assembly, while stable with respect to gentle rinsing in aqueous buffer, is reversible and the lipid adlayer is removable by immersion in a solvent such as ethanol.
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CAS 67232-80-8 1,2-Dimyristoyl-rac-glycero-3-phospho-rac-(1-glycerol) sodium salt

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