1,2,3,4,6-Penta-O-acetyl-a-D-fructofuranose - CAS 58670-14-7
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a-D-Fructofuranose pentaacetate
1.Galectin-3 and prediction of therapeutic response to renal sympathetic denervation.
Schwerg M1, Eilers B2, Wienecke A1, Baumann G1, Laule M1, Knebel F1, Stangl K1, Stangl V1. Clin Exp Hypertens. 2016 May 9:1-5. [Epub ahead of print]
The profibrotic mediator Galectin-3 (Gal-3) has been associated with aldosterone-mediated vascular inflammation, fibrosis, and stiffness. We evaluated whether the Gal-3 levels and change in Gal-3 as associated with renal denervation can serve as prediction of therapeutic response to renal denervation. A total of 42 patients with resistant hypertension undergoing renal sympathetic denervation (RDN) were included. Blood pressure was evaluated by 24-h ambulatory measurement before RDN and 1, 3 and 6 months after RDN. Treatment response was defined as a drop in systolic ambulatory blood pressure of >5 mm Hg after 6 months. Blood samples were assessed for Gal-3 levels. For the entire group, a significant drop in mean systolic ambulatory blood pressure of 5.2 ± 18.6 mm Hg was observed (p = 0.032). The responder rate was 50% (n = 21). At baseline, Gal-3 levels were significantly higher in responders (14.5 ± 6.0 vs. 10.95 ± 4.6 ng/ml, p = 0.017).
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CAS 58670-14-7 1,2,3,4,6-Penta-O-acetyl-a-D-fructofuranose

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