Ziprasidone mesilate - CAS 199191-69-0

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Category
APIs
Product Name
Ziprasidone mesilate
Catalog Number
199191-69-0
Synonyms
5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one;methanesulfonic acid;trihydrate; 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one, methanesulfonate, trihydrate; CP88059; CP-88059; CP 88059; CP-88,059; CP-88,059-01; CP88059 hydrochloride; Ziprasidone HCl, brand name: Geodon; Zeldox; Zipwell; 146939-27-7 (Ziprasidone free base); 122883-93-6 (Ziprasidone HCl salt); 138982-67-9 (Ziprasidone HCl hydrate); 199191-69-0 (Ziprasidone Mesylate Trihydrate)
CAS Number
199191-69-0
Description
Ziprasidone, an antipsychotic agent chemically unrelated to phenothiazine or butyrophenone antipsychotic agents, exhibited high in vitro binding affinity for the dopamine D2 and D3, the serotonin 5HT2A, 5HT2C, 5HT1A and 5HT1D and α1-adrenergic receptors (Kis of 4.8, 7.2, 0.4, 1.3, 3.4, 2, and 10 nM, respectively) and moderate affinity for the histamine H1 receptor (Ki=47 nM). Approved for the treatment of schizophrenia, and acute mania and mixed states associated with bipolar disorder, Ziprasidone functioned as an antagonist at the D2, 5HT2A, and 5HT1D receptors, and as an agonist at the 5HT1A receptor. In addition, Ziprasidone inhibited synaptic reuptake of serotonin and noradrenaline.
Molecular Weight
563.087
Molecular Formula
C22H25ClN4O4S2.3H2O
COA
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MSDS
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Canonical SMILES
CS(=O)(=O)O.C1CN(CCN1CCC2=C(C=C3C(=C2)CC(=O)N3)Cl)C4=NSC5=CC=CC=C54.O.O.O
InChI
1S/C21H21ClN4OS.CH4O3S.3H2O/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21;1-5(2,3)4;;;/h1-4,11,13H,5-10,12H2,(H,23,27);1H3,(H,2,3,4);3*1H2
InChIKey
WLQZEFFFIUHSJB-UHFFFAOYSA-N
Targets
Dopamine Receptor; 5-HT Receptor
Structure
CAS 199191-69-0 Ziprasidone mesilate
Specification
Purity
>98%
Appearance
Solid powder
Solubility
in 30% (w/v) sulfobutyl betadex sodium (SBECD) was determined to be 45 mg/mL
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