Alkaloid , from plants of the Ungernia genus, Amaryllidaceae.
Potent inhibitor of Ca2+ release from sarcoplasmic reticulum
PBD dimer is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates.
Auristatin E is a synthetic analog of dolastatin 10. Auristatin E is a highly potent antimitotic agent.Auristatin E inhibits tubulin polymerization. Auristatin ...
Carothane complex ester , from plants of the Umbelliferae family.
Topotecan has been used as a positive control for the identification and analysis of HIF-1α and VEGF inhibitors in human glioma cells under hypoxic conditions. ...
Diacetylkorseveriline is an antiarrhythmic (classes i and iv), belonging to a novel structural class. effective against arrhythmia caused by aconitine,CaCl2, el...
Alkaloid, Tetrahydroisoquinoline, Active dopamine metabolite, Cholinesterase inhibitor
A Na+ channel blocker; potent antiarrhythmic, inhibits voltage-gated Na+ channels in rat brain synaptosomes.
Cyclopiazonic acid is a mycotoxin produced by molds including certain species of Penicillium and Aspergillus. Its toxicity is linked to its ability to specifica...
Anhydroperforine from the seeds of Haplophyllum perforatum.
Lycoctonine is a plant alkaloid and a precursor to the ABC ring system of taxoids.
Margatoxin (MgTx) is a component of the venom of Scorpio Centruroides margaritatus. Margatoxin preferentially inhibits voltage-dependent potassium channels Kv1....
A natural compound extracted from Phellodendron chinense, exhibits a near planar framework
Synthetic, an inhibitor of monoamine oxydase.Enhances the toxicity of the Phenamine group and of Tryptamine.
Quinoline alkaloid, extracted from Haplophyllum bucharicum (Rutacae)
Nitrodienamine, an inhibitor of Ca2+/Mg2+ ATPase.
PF-06380101 is a novel cytotoxic Dolastatin 10 analogue; with excellent potencies in tumor cell proliferation assays and differential ADME properties when compa...
Synthetic, an inhibitor of high-affinity choline uptake (HAChU) in synaptosomes.
Synthetic, GABAA-gated Cl- channels blocker; non-competitive GABAA antagonist.