1. Triamcinolone–carbon nanotube conjugation inhibits inflammation of human arthritis synovial fibroblasts
Yeon Kyung Lee, Jin Kyeong Choi, Dongwoo Khang*, Sang-Hyun Kim*. J. Mater. Chem. B, 2016, 4, 1660—1671
Current therapeutics are administered by oral or intraarticular routes and include five main classes of drugs: corticosteroids, analgesics, non-steroidal anti-inflammatories, and non-biologic and biologic disease-modifying anti-rheumatic drugs. Corticosteroids are very potent anti-inflammatory agents and intra-articular corticosteroid injections have been widely used for nearly six decades for symptomatic arthritis. Favorable reports on the use of intra-articular steroid injections in arthritis are numerous and the evidence supports their use for rheumatoid arthritis (1A + level) and osteoarthritis (1A + level). In particular, triamcinolone (TA) is commonly used since it is the least soluble corticosteroid that is injectable within joints and has a superior anti-inflammatory eﬀect through prolonged drug release.
2. Analysis of corticosteroids by high performance liquid chromatography–electrospray mass spectrometry
Alessia Panusa, Monica Ottaviani, Domenica Tonelli*. Analyst , 2004, 129 , 719–723
Due to the lack of reference standards, the corticosteroid agents can hardly be detected with conventional analytical techniques such as HPLC equipped with an UV detector. Furthermore, they have similar UV spectra, low molar absorptivities, and their peak areas could be negligible at the concentrations usually utilised in illegal beauty products. In this case, the LC-MS technique is a powerful tool which allows also for the detection of lower concentrations. In the above described method, a simple linear gradient based on water–acetonitrile as mobile phase, was sufficient to obtain a good separation of triamcinolone and four of its esters which were identified by ESI-MS in negative ionization polarity. The analysis of shampoo samples enabled us to identify the presence of triamcinolone hexacetonide in one of them and to assess the specificity of the method. Taking into consideration the recoveries and the limits of detection obtained for each compound, it would be possible to identify triamcinolone or its derivatives down to 0.01% (w/w) in a real cosmetic.