PF-05241328, a purely acidic molecule, is a selective inhibitor of human Nav1. 7 voltage-dependent sodium channels (IC50= 31nM) for the treatment of pain. But P...
Tetrodotoxin, citrate (1:1) (salt)
Tetrodotoxin, citrate (1:1) (salt), also called as TTX citrate, is the citrate salt of tetrodotoxin. Tetrodotoxin is a neurotoxin that reversibly and selectivel...
Funapide is a Nav1.7 and Nav1.8 voltage-gated sodium channel inhibitor under the development by Xenon Pharmaceuticals and Teva Pharmaceutical Industries. It is ...
This active molecular is a calcium channel antagonist with sodium channel stimulating property as a dihydropyridine. PD 122860 can increase left ventricular con...
Evenamide is a selective voltage-gated sodium and/or calcium channel modulator, including subtypes Nav1.3, Nav1.7, and Nav1.8. It may be potentia useful in pre...
Proparacaine Hydrochloride is a topical ophthalmic anesthetic, acting by inhibiting the voltage-gated sodium channels. IC50(ED50): 3.4 mM.
Raxatrigine is a novel analgesic for the treatment of lumbosacral radiculopathy (sciatica) and trigeminal neuralgia. It acts as a selective, small-molecule, sta...
Oxcarbazepine inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50...
Mephenytoin is known to target sodium channel protein type 5 subunit alpha. It is a hydantoin-derivative anticonvulsant used to control various partial seizures...
Ethotoin is an anticonvulsant drug. It is a sodium channel inhibitor. Ethotoin can be used for the treatment of epilepsy. It is a hydantoin, similar to phenytoi...
Amiloride, a pyrazine derivative potassium-sparing diuretic, is a blocker of sodium channel in renal epithelial cells. Amiloride blocked the low threshold Ca2+ ...
Vinpocetine is a Phosphodiesterase inhibitor and selective for PDE1. It also blocks voltage-gated Na+ channels.
CGP-47292, a triazole compound, has been found to be a metabolite of CGP-33101 that could be used agaist Lennox-Gastaut syndrome as a Sodium Channel antagonist.
Mexiletine HCl belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current.
Lamotrigine is an anticonvulsant, inhibiting glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.
Eleclazine is a selective Sodium channel antagonist. Eleclazin showed a shortening of the QTc interval (the time interval between the start of the Q-wave and en...
PH-064 is a sodium channel inhibitor. It is extracted from patent FR 2879460 A1.
Lidocaine hydrochloride monohydrate
Lidocaine hydrochloride monohydrate is the hydrochloride monohydrate form of lidocaine, which is an aminoethylamide and a prototypical member of the amide class...
Dibucaine HCl is a local anesthetics.Among the most potent and toxic of the long-acting local anesthetics, current use of it is generally restricted to spinal a...
GSK-1014802 hydrochloride is the hydrochloride form of GSK-1014802, which is a novel analgesic for the treatment of lumbosacral radiculopathy (sciatica) and tri...