GS967, also known as GS-458967, is a highly selective late sodium channel current blocker. The selective inhibition of late INa with GS967 can exert antiarrhyth...
This active molecular is a calcium channel antagonist with sodium channel stimulating property as a dihydropyridine. PD 122860 can increase left ventricular con...
Mephenytoin is known to target sodium channel protein type 5 subunit alpha. It is a hydantoin-derivative anticonvulsant used to control various partial seizures...
GSK-1014802 hydrochloride is the hydrochloride form of GSK-1014802, which is a novel analgesic for the treatment of lumbosacral radiculopathy (sciatica) and tri...
Ropivacaine hydrochloride is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.
ICA-121431 is a potent and selective inhibitor of human NaV1.3 (IC50=13 nM) and NaV1.1 channels (IC50=23 nM) with 1,000 fold selectivity against other resistant...
CGP-47292, a triazole compound, has been found to be a metabolite of CGP-33101 that could be used agaist Lennox-Gastaut syndrome as a Sodium Channel antagonist.
Propafenone is a Class 1C antiarrhythmic as sodium channel blocker by slowing the influx of sodium ions into the cardiac muscle cells.
Co 102862, also known as V102862, an orally active anticonvulsant with robust activity, is a potent, broad-spectrum state-dependent inhibitor of mammalian volta...
Lamotrigine is an anticonvulsant, inhibiting glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.
Ranolazine is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.
Lidocaine hydrochloride monohydrate
Lidocaine hydrochloride monohydrate is the hydrochloride monohydrate form of lidocaine, which is an aminoethylamide and a prototypical member of the amide class...
Disopyramide phosphate is an oral antiarrhythmic agent for the treatment of cardiac arrhythmias. Disopyramide is a sodium channel blocker and therefore classifi...
Elpetrigine, also known as GW 273293 and JZP-4, has a blocking effect on calcium channels and potassium channels which has been in clinical bipolar disorders an...
A-803467 is a sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50=140 nM).
Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.
Proparacaine Hydrochloride is a topical ophthalmic anesthetic, acting by inhibiting the voltage-gated sodium channels. IC50(ED50): 3.4 mM.
This active molecular is a human Nav1.7 voltage gated sodium channel inhibitor with the IC50 value of 28 nM. PF-04856264 inhibits the Nav channel by interacting...
Propafenone D7 hydrochloride
The hydrochloride salt form of D7 labelled Propafenone which is a sodium channel blocker and commonly used in the treatment of arrhythmia.
Encainide Hydrochloride is a sodium channel blocker and class Ic antiarrhythmic agent. It is a non-chiral and benzanilide derivative. It blocks voltage-gated so...