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Taltobulin - CAS 228266-40-8

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Category
ADCs
Product Name
Taltobulin
Catalog Number
228266-40-8
CAS Number
228266-40-8
Description
Taltobulin, also known as HTI-286 and SPA-110, is a fully synthetic analog of the natural tripeptide hemiasterlin, inhibits tubulin polymerization and circumvents transport-based resistance to taxanes. HTI-286 was a potent inhibitor of proliferation (mean IC50 = 2.5 ± 2.1 nm in 18 human tumor cell lines) and had substantially less interaction with multidrug resistance protein (P-glycoprotein) than currently used antimicrotubule agents, including paclitaxel, docetaxel, vinorelbine, or vinblastine.
Molecular Weight
473.32
Molecular Formula
C27H43N3O4
COA
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MSDS
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Structure
CAS 228266-40-8 Taltobulin
Specification
Purity
≥98.0% (HPLC)
Appearance
White solid powder
Application
ADCs Cytotoxin
Storage
Dry, dark and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).
Solubility
Soluble in DMSO, not in water
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