|Synonyms||NSC 25485; 2,3,10,11,12,13-hexahydro-10R-methoxy-9S-methyl-11R-methylamino-9S,13R-epoxy-1H,9H-diindolo[1,2,3-gh;3’,2’,1’-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one;|
|Description||Staurosporine is broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC50 = 3 nM), protein kinase A (IC50 = 7 nM), p60v-src tyrosine protein kinase (IC50 = 6 nM) and CaM kinase II (IC50 = 20 nM).|
Batrachotoxin (BTX) is an extremely potent cardiotoxic and neurotoxic steroidal alkaloid found in certain species of frogs, melyrid beetles, and birds.Batrachot...
Sevedindione presents an antiarrhythmic activity on arrhythmias caused by Aconitine.
Topotecan has been used as a positive control for the identification and analysis of HIF-1α and VEGF inhibitors in human glioma cells under hypoxic conditions. ...
DM 4 is an intermediate used to prepare semisynthetic maytansine analogs which can be conjugated with antibodies for the targeted treatment of cancer.
Hydrochloride salt of DL-Tetrahydropalmatine is the main active substance of the Chinese herb corydalis which induces hypotension and bradycardia in rats throug...
Synthetic, a potent inhibitor of high-affinity choline uptake (HAChU) in synaptosomes.
Calciseptine is a natural neurotoxin isolated from the black mamba Dendroaspis p. polylepis venom. This toxin consists of 60 amino acids with four disulfide bon...
Hyoscyamine is a tropane alkaloid. It is a secondary metabolite found in certain plants of the family Solanaceae, non-selective antagonist at Muscarinic recepto...
Synthetic, a neuronal nicotinic AChR antagonist.
Sanguinarine is a toxic quaternary ammonium salt from the group of benzophenanthridine alkaloids. It is extracted from some plants, including bloodroot (Sanguin...
Diterpenoid alkaloids from the roots of Delphinium scabriflorum.
DM4 is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates.
Ducamycin Analog is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates.
Amiloride HCl is a relatively selective inhibitor of the epithelial sodium channel, used in the management of hypertension and congestive heart failure.
DM3 is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates.
Seco-Duocarmycin TM is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates.
Synthetic, a selective irreversible inhibitor of carboxylesterases
Mebicyphat is shown to be a non-competitive GABA antagonist. Blocks GABA gated Cl- channels, and is shown to inhibit dihydropicrotoxin
Extracted from Haplophyllum perforatum plant (Rutaceae fam.). An antiarrhythmic of first class Quinoline alkaloid
A Norditerpenoid alkaloid. Nicotinic receptor antagonist at the neuromuscular junction and vegetative ganglia; hypotensive. Diterpene alkaloid , from plants of ...