Mesaconitine has antinociceptive activity through cyclic AMP and stimulation of the central β-adrenergic system.
Norfluorocurarine is a peripheral vasodilator that increases blood flow to the brain (sold under the trademark Oxybral SR) .<br/>Generic drugs containing vincam...
Steroidal Alkaloid from Convolvulus krauseanus
Gramine is a naturally occurring indole alkaloid present in several plant species. Gramine may play a defensive role in these plants, since it is toxic to many ...
Mebicyphat is shown to be a non-competitive GABA antagonist. Blocks GABA gated Cl- channels, and is shown to inhibit dihydropicrotoxin
Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium c...
Synthetic, an inhibitor of high-affinity choline uptake (HAChU) in synaptosomes.
Alkaloid from reticuline and is a precursor of berberine.It has also been found to be a GABAA receptor agonist.
Non-selective K+ channel blocker.
Tropane alkaloid, from plants of the Convolvulus genus,
Alkaloid, Tetrahydroisoquinoline, Active dopamine metabolite, Cholinesterase inhibitor
DM4 is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates.
Gossypol Acetic Acid
an antiviral at low concentration; antiherpes, antipsoriasis and antikeratitis, male contraceptive. Polyphenol , from plants of the Gossypium genus, Malvaceae.
Daunorubicin(RP13057) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.
Chlorotoxin (Cltx) is a neurotoxin that was originally isolated from the venom of Leiurus quinquestriatus. Chlorotoxin is a specific ligand of glioma cells. Chl...
Microcystin-RR inhibits PP1C, PP1γ, and PP2A with Ki values of 0.15, 0.24, and 0.018 nM, respectively.
Synthetic, a selective irreversible inhibitor of carboxylesterases
Agitoxin-2 is a potent and selective blocker of the Shaker type voltage-gated Kv1.3 and Kv1.1 channels. Agitoxin-2 inhibits Kv1.3 with an IC50 value of around 2...
A proanthocyanidin from Polygonum coriaricum, an antihypoxic.
Anti-tumor effect of hernandezine and other components extracted from Thalictrum glandulosissimum.