|Synonyms||BMS-442606; 8-Azaspiro(4.5)decane-7,9-dione, 6-hydroxy-8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, (6S)-;|
|Description||(S)-6-Hydroxybuspirone is a major active metabolite of Buspirone. (R)-Enantiomer showed higher affinity and selectivity for the 5HT1A receptor compared to the (S)-enantiomer; while (S)-Enantiomer has advantage of being cleared more slowly from blood compared to the (R)-enantiomer|
|Quality Standard||Enterprise standard|
|Current Developer||Bristol-Myers Squibb|
Rupatadine inhibits both platelet-activating factor (PAF) and histamine (H1) effects through its interaction with specific receptors.
Thesuccinate salt form of Frovatriptan, a carbazole derivative, has been found to be a 5-HT receptor agonist that could be used as an antimigraine agent.
Elzasonan citrate is a selective 5-hydroxytryptamine 1B receptor antagonist for treat patients with major depressive disorder and obsessive compulsive disorder.
Tedatioxetine is an antidepressant agent. It acts as a triple reuptake inhibitor and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist. It was discov...
Rizatriptan Benzoate is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.
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Quetiapine sulfoxide dihydrochloride
Quetiapine sulfoxide dihydrochloride, a metabolite of Quetiapine, has antipsychotic effect.
Way 100289 is a selective Serotonin 3 receptor antagonist originated by Wyeth. No development for the treatment of Anxiety disorders, Learning disorders and Psy...
Pindolol, an Indole derivative, could be used in the treatment of hypertension and arrhythmia for acting as a 5-HT1A/1B receptor antagonist. IC50: 33nM(Ki).
This active molecular is a serotonin 5-HT1A antagonist. LY 206130 (3.0 mg/kg, s.c.) alone significantly increased norepinephrine level by 60%, dopamine levels b...
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The hydrochloride salt form of CP-809101 which is a selective 5-HT2C receptor agonist which probably shows antipsychotic activity and restrains amphetamine-stim...
SB-269970 is a selective 5-HT7 receptor antagonist (pKi of 8.3) with >50-fold selectivity against other receptors, on amphetamine and ketamine-induced hyperacti...
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Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.oxapine is a typical antipsych...
LY 302148 is a 5-HT1F receptor agonist with potential for migraine therapeutics.
The hydrochloride salt form of Sarpogrelate, a 5-HT2 antagonist, could be used as an antiplatelet agent and other sorts of disease like angina pectoris, diabete...
Way 100135 is a selective 5-HT1A receptor antagonist originated by Wyeth with IC50 value of 15 nM. IC 50 values for 5-HT1B, 1C, 2,α1, α2 and D2 receptors are ov...