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(S)-3,4-DCPG - CAS 201730-11-2

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Category
Main Product
Product Name
(S)-3,4-DCPG
Catalog Number
201730-11-2
Synonyms
(S)-3,4-DICARBOXYPHENYLGLYCINE; (S)-3,4-DCPG; UBP1109
CAS Number
201730-11-2
Molecular Weight
239.18
Molecular Formula
C10H9NO6
COA
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MSDS
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Canonical SMILES
C1=CC(=C(C=C1C(C(=O)O)N)C(=O)O)C(=O)O
InChI
InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1
InChIKey
IJVMOGKBEVRBPP-ZETCQYMHSA-N
Structure
CAS 201730-11-2 (S)-3,4-DCPG
Specification
Purity
≥99%
Appearance
White solid
Reference Reading
1.The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease.
Johnson KA1, Jones CK, Tantawy MN, Bubser M, Marvanova M, Ansari MS, Baldwin RM, Conn PJ, Niswender CM. Neuropharmacology. 2013 Mar;66:187-95. doi: 10.1016/j.neuropharm.2012.03.029. Epub 2012 Apr 21.
Metabotropic glutamate receptors (mGlus) are 7 Transmembrane Spanning Receptors (7TMs) that are differentially expressed throughout the brain and modulate synaptic transmission at both excitatory and inhibitory synapses. Recently, mGlus have been implicated as therapeutic targets for many disorders of the central nervous system, including Parkinson's disease (PD). Previous studies have shown that nonselective agonists of group III mGlus have antiparkinsonian effects in several animal models of PD, suggesting that these receptors represent promising targets for treating the motor symptoms of PD. However, the relative contributions of different group III mGlu subtypes to these effects have not been fully elucidated. Here we report that intracerebroventricular (icv) administration of the mGlu(8)-selective agonist (S)-3,4-dicarboxyphenylglycine (DCPG [ 2.5, 10, or 30 nmol]) does not alleviate motor deficits caused by acute (2 h) treatment with haloperidol or reserpine.
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