Rupatadine fumarate - CAS 182349-12-8

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Category
APIs
Product Name
Rupatadine fumarate
Catalog Number
182349-12-8
CAS Number
182349-12-8
Molecular Weight
532.03
Molecular Formula
C26H26ClN3·C4H4O4
Quality Standard
-
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Structure
CAS 182349-12-8 Rupatadine fumarate
Specification
Appearance
White solid
Reference Reading
1.Antihistaminic effects of rupatadine and PKPD modelling
JUANA PENAl, MARCEL•LI CARBO. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 2008, Vol. 33, No.2, pp. 107-116
Data on rupatadine and desloratadine plasma con-centrations from two different clinical trials were combined in order to perform the pharmacokinetic modelling. In previous studies assessing the antihistaminic activity of rupatadine, doses of 10, 20, 40 and 80 mg rupatadine fumarate were administered, although the concentrations of the drug and its metabolite were only determined in plasma samples at the two highest doses. Other data were taken from a later bioequivalence study between solution and tablet form, where 10 mg rupatadine was administered (data not published). Concentration data from 30 healthy volunteers (18 males and 12 females, age range 18 to 44 years) coming from the two clinical trials mentioned above were used for the development of the population pharmacokinetic model.
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