1. Micelle promoted multicomponent synthesis of 3-amino alkylated indoles via a Mannich-type reaction in water
Atul Kumar,* Maneesh Kumar Gupta, Mukesh Kumar and Deepti Saxena. RSC Adv., 2013, 3, 1673–1678
Theindolenucleus is an important structural unit that is present in a number of drugs currently on the market. Most of these belong to the 3-substituted indole family, which is an important intermediate for chemical synthesis and widely distributed in many important natural products. Besides, this 3-substituted indole is also an important class of pharmacophores having many biological activities i.e. Sumatriptan, Frovatriptan, Zolmitriptan and Rizatriptan are used for migraine headaches, whereas azolylbenzyl indole and bis-indole are used as a breast cancer and HIV-1 integrase inhibitor, respectively.