(R)-(+)-Tolterodine - CAS 124937-51-5
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
(R)-(+)-Tolterodine
Catalog Number:
124937-51-5
Synonyms:
(+)-Tolterodine; (R)-Tolterodine; PNU-200583
CAS Number:
124937-51-5
Description:
A muscarinic receptor antagonist. Used in the treatment of urinary incontinence.
Molecular Weight:
325.49
Molecular Formula:
C22H31NO
COA:
Inquire
MSDS:
Inquire
Targets:
mAChR
Chemical Structure
CAS 124937-51-5 (R)-(+)-Tolterodine

Related mAChR Products


CAS 22254-24-6 Ipratropium bromide

Ipratropium bromide
(CAS: 22254-24-6)

Ipratropium bromide, under the trade name Atrovent, structurally similar to atropine, is a muscarinic antagonist and a bronchodilator.

CAS 57381-26-7 Irsogladine

Irsogladine
(CAS: 57381-26-7)

Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reductio...

CAS 55869-99-3 Anisodamine

Anisodamine
(CAS: 55869-99-3)

Anisodamine is a alkaloid shown to be a weak antagonist of α1-adrenoceptors, blocking WB-4101 and clonidine by binding in brain membrane preparations.

CAS 26095-59-0 Otilonium Bromide

Otilonium Bromide
(CAS: 26095-59-0)

Otilonium Bromide is an antimuscarinic used as a spasmolytic agent.

CAS 60-31-1 Acetylcholine Chloride

Acetylcholine Chloride
(CAS: 60-31-1)

Acetylcholine is an organic molecule that acts as a neurotransmitter in many organisms, including humans.

CAS 385367-47-5 Tarafenacin

Tarafenacin
(CAS: 385367-47-5)

Tarafenacin is a highly selective M3 muscarinic receptor antagonist. It was the most potent in inhibiting carbachol-induced bladder contractions of the anti-ch...

CAS 107233-08-9 Cevimeline

Cevimeline
(CAS: 107233-08-9)

Cevimeline is a selective M1 receptor agonist.

CAS 76-90-4 Mepenzolate Bromide

Mepenzolate Bromide
(CAS: 76-90-4)

Mepenzolate Bromide is a muscarinic antagonist used to treat gastrointestinal disorders, and decreases the severity of elastase-induced airspace enlargement and...

CAS 5633-20-5 Oxybutynin

Oxybutynin
(CAS: 5633-20-5)

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.

CAS 144-11-6 Trihexylphenedyl

Trihexylphenedyl
(CAS: 144-11-6)

Trihexyphenidyl is a Mucarinic Cholinergic receptor antagonist using for the treatment of Parkinson's disease. It also has a direct antispasmodic action on smoo...

CAS 869113-09-7 Umeclidinium bromide

Umeclidinium bromide
(CAS: 869113-09-7)

Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD).

CAS 51-56-9 Homatropine Bromide

Homatropine Bromide
(CAS: 51-56-9)

Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 1...

CAS 170105-16-5 Imidafenacin

Imidafenacin
(CAS: 170105-16-5)

Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM).

CAS 155-41-9 Methscopolamine

Methscopolamine
(CAS: 155-41-9)

Methscopolamine is a muscarinic acetylcholine receptor blocker.

CAS 634616-95-8 TBPB

TBPB
(CAS: 634616-95-8)

TBPB is an allosteric M1 mAChR agonist that regulates amyloid processing and produces antipsychotic-like activity in rats.

PF-06767832
(CAS: 1859081-58-5)

PF-06767832 is a cell permeable, potent and selective M1 muscarinic acetylcholine receptor Positive Allosteric Modulator (PAM).

CAS 5908-99-6 Atropine sulfate salt monohydrate

Atropine sulfate salt monohydrate
(CAS: 5908-99-6)

Atropine is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 2.5 nM.

CAS 1508-65-2 Oxybutynin chloride

Oxybutynin chloride
(CAS: 1508-65-2)

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.

CAS 125-53-1 oxyphencyclimine

oxyphencyclimine
(CAS: 125-53-1)

Oxyphencyclimine is a muscarinic cholinergic receptor antagonist and trade name is called as Daricon. Now it is applicated for the treatment of peptic ulcers an...

CAS 10405-02-4 Trospium chloride

Trospium chloride
(CAS: 10405-02-4)

Trospium chloride is a competitive muscarinic cholinergic receptor antagonist.

Reference Reading


1.Mast cell activation and response to tolterodine in the rat urinary bladder in a chronic model of intravesical protamine sulfate and bacterial endotoxin-induced cystitis.
Choi BH1, Jin LH2, Kim KH3, Han JY4, Kang JH1, Yoon SM5, Park CS1, Lee T5. Mol Med Rep. 2014 Aug;10(2):670-6. doi: 10.3892/mmr.2014.2262. Epub 2014 May 22.
The aim of the present study was to use an animal model of interstitial cystitis (IC) in order to investigate the histology and function of the bladder, with a particular focus on mast cell degranulation and response to detrusor overactivity (DO) to tolterodine. A total of 18 female Sprague‑Dawley rats were used. In 12 rats, lipopolysaccharide (LPS) was intravesically instilled following the induction of IC by protamine sulfate (PS) and six rats were subjected to sham instillations. Following 1 month, cystometry was performed. The effects of tolterodine were tested in half of the animals with IC. All rats in the IC group demonstrated DO during the filling phase and no significant changes in the frequency or pressure compared with that following tolterodine injection were identified. Histological examination revealed a significant increase in the total number of infiltrated mast cells in IC rats compared with that in the sham rats (P<0.
2.Selective inhibitory effect of imidafenacin and 5-hydroxymethyl tolterodine on capsaicin sensitive C fibers of the primary bladder mechanosensitive afferent nerves in the rat.
Aizawa N1, Ito H1, Sugiyama R1, Fujimura T1, Suzuki M1, Fukuhara H1, Homma Y1, Igawa Y2. J Urol. 2015 Apr;193(4):1423-32. doi: 10.1016/j.juro.2014.09.005. Epub 2014 Sep 16.
PURPOSE: Imidafenacin and fesoterodine are used to treat overactive bladder. Imidafenacin, fesoterodine and its active metabolite 5-hydroxymethyl tolterodine are muscarinic receptor antagonists. It is believed that these agents act on afferent nerves in addition to smooth muscle. We investigated the effects of imidafenacin and 5-hydroxymethyl tolterodine on single unit afferent activity of mechanosensitive capsaicin sensitive and insensitive primary bladder afferent nerve fibers in rats.