(R)-3-amino-1-benzylpyrrolidine dihydrochloride - CAS 215947-36-7
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1.Structural Diversity and Properties of M(II) Coordination Compounds Constructed by 3-Hydrazino-4-amino-1,2,4-triazole Dihydrochloride as Starting Material.
Xu C1, Zhang J1, Yin X1, Cheng Z2. Inorg Chem. 2015 Dec 15. [Epub ahead of print]
Twelve metal coordination compounds with two triazole derivatives, namely, {[Mn(HATr)2](ClO4)2}n (1), [Mn(HATr)3]Cl(ClO4) (2), [Co3(ATr)6(H2O)6](ClO4)6·4.5H2O (3), [Co(HATr)3]Cl(ClO4) (4), [Co2Cl2(HATr)2(H2O)2(CH3OH)2]Cl2·2H2O (5), [Ni3(ATr)6(H2O)6](ClO4)6·4.5H2O (6), [Ni(HATr)3]Cl(ClO4) (7), [Ni2Cl2(HATr)2(H2O)4](ClO4)2·4H2O (8), [Ni2(HATr)2(H2O)6](ClO4)4·2H2O (9), {[Zn(HATr)2](ClO4)2}n (10), [Zn(HATr)3]Cl(ClO4) (11), and {[Cd4(HATr)8](CdCl4)Cl2(ClO4)4}n (12), when HATr = 3-hydrazino-4-amino-1,2,4-triazole and ATr = 4-amino-1,2,4-triazole, were prepared under diverse conditions and structurally characterized. Compounds 1, 10 and 12 exhibit one-dimensional zigzag chain structures; 2, 4, 7, and 11 possess mononuclear structures; 3 and 6 display trinuclear structures, while 5, 8, and 9 feature binuclear structures. Hydrogen bonds link these compounds into three-dimensional structures. The thermal stability and energetic properties also were determined.
2.Automated determination of nitrate plus nitrite in aqueous samples with flow injection analysis using vanadium (III) chloride as reductant.
Wang S1, Lin K1, Chen N1, Yuan D1, Ma J2. Talanta. 2016 Jan 1;146:744-8. doi: 10.1016/j.talanta.2015.06.031. Epub 2015 Jun 17.
Determination of nitrate in aqueous samples is an important analytical objective for environmental monitoring and assessment. Here we report the first automatic flow injection analysis (FIA) of nitrate (plus nitrite) using VCl3 as reductant instead of the well-known but toxic cadmium column for reducing nitrate to nitrite. The reduced nitrate plus the nitrite originally present in the sample react with the Griess reagent (sulfanilamide and N-1-naphthylethylenediamine dihydrochloride) under acidic condition. The resulting pink azo dye can be detected at 540 nm. The Griess reagent and VCl3 are used as a single mixed reagent solution to simplify the system. The various parameters of the FIA procedure including reagent composition, temperature, volume of the injection loop, and flow rate were carefully investigated and optimized via univariate experimental design. Under the optimized conditions, the linear range and detection limit of this method are 0-100 µM (R(2)=0.
3.In vitro study on the disinfectability of two split-septum needle-free connection devices using different disinfection procedures.
Engelhart S1, Exner M1, Simon A2. GMS Hyg Infect Control. 2015 Dec 9;10:Doc17. doi: 10.3205/dgkh000260. eCollection 2015.
in English, GermanIn einer Reihe von in vitro-Versuchen wurde die Desinfizierbarkeit von zwei nadelfreien Split-Septum-Konnektionsventilen (NFC) mit einem Hautantiseptikum auf Basis von Octenidindihydrochlorid 0,1 g, 1-Propanol 30,0 g und 2-Propanol 45,0 g in 100 g Lösung mittels Sprüh- und Wischdesinfektion mit steriler Kompresse vs. Wischdesinfektion mit vorgetränkten Läppchen mit 63,1 g 2-Propanol in 100 ml Lösung untersucht. Dabei wurde die äußere Membran des NFC mit >105 KbE K. pneumoniae oder S. epidermidis kontaminiert. Die Überprüfung des Desinfektionserfolgs bei einer Einwirkungszeit von 30 Sek. erfolgte mittels Abstrich und Durchspülmethode. Die Desinfektion mit dem Hautantiseptikum erwies sich in Bezug auf beide Bakterienspezies als hocheffektiv. Hingegen konnte nach der hier durchgeführten Methode der Desinfektion mit vorgetränkten Läppchen in einigen Versuchsreihen mit S. epidermidis keine ausreichende Dekontamination beider NFC-Typen erreicht werden.
4.Reduction of cytotoxicity of benzalkonium chloride and octenidine by Brilliant Blue G.
Bartok M1, Tandon R1, Alfaro-Espinoza G1, Ullrich MS1, Gabel D1. EXCLI J. 2015 Jan 21;14:123-32. doi: 10.17179/excli2014-556. eCollection 2015.
The irritative effects of preservatives found in ophthalmologic solution, or of antiseptics used for skin disinfection is a consistent problem for the patients. The reduction of the toxic effects of these compounds is desired. Brilliant Blue G (BBG) has shown to meet the expected effect in presence of benzalkonium chloride (BAK), a well known preservative in ophthalmic solutions, and octenidine dihydrochloride (Oct), used as antiseptic in skin and wound disinfection. BBG shows a significant protective effect on human corneal epithelial (HCE) cells against BAK and Oct toxicity, increasing the cell survival up to 51 % at the highest BAK or Oct concentration tested, which is 0.01 %, both at 30 min incubation. Although BBG is described as a P2x7 receptor antagonist, other selective P2x7 receptor antagonists, OxATP (adenosine 5'-triphosphate-2',3'-dialdehyde) and DPPH (N'-(3,5-dichloropyridin-4-yl)-3-phenylpropanehydrazide), did not reduce the cytotoxicity of neither BAK nor Oct.
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CAS 215947-36-7 (R)-3-amino-1-benzylpyrrolidine dihydrochloride

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