propan-2-yl 3-phenylprop-2-enoate - CAS 7780-06-5
Catalog number: 7780-06-5
Category: Main Product
Molecular Formula:
C12H14O2
Molecular Weight:
190.24
COA:
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Purity:
>98.0%(GC)
Appearance:
clear yellow liquid
Synonyms:
1-methylethyl3-phenyl-2-propenoate; 2-Propenoicacid,3-phenyl-,1-methylethylester; 3-phenyl-2-propenoicaci1-methylethylester; Isopropyl (2E)-3-phenyl-2-propenoate; Isopropylester kyseliny skoricove; isopropylesterkyselinyskoricove; ISOPROPYL CINNAMATE, 98; ISOPR
MSDS:
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Quantity:
Data not available, please inquire.
Boiling Point:
268.999ºC at 760 mmHg
Density:
1.02 g/mL at 25 °C(lit.)
1.Crystal structure of 6-chloro-5-(2-chloro-eth-yl)-3-(propan-2-yl-idene)indolin-2-one.
Roopashree KR1, Meti GY2, Kamble RR2, Devarajegowda HC1. Acta Crystallogr E Crystallogr Commun. 2015 Jul 22;71(Pt 8):o592-3. doi: 10.1107/S2056989015012268. eCollection 2015.
The title compound, C13H13Cl2NO, has a 3-(propan-2-yl-idene)indolin-2-one core with a Cl atom and a chloro-ethyl substituent attached to the aromatic ring. Two atoms of the aromatic ring and the chloro-ethyl substituent atoms are disordered over two sets of sites with a refined occupancy ratio of 0.826 (3):0.174 (3). In the crystal, mol-ecules are linked by pairs of N-H⋯O hydrogen bonds, forming inversion dimers with an R 2 (2)(8) ring motif.
2.Effects on MC3T3-E1 Cells and In silico Toxicological Study of Two 6-(Propan-2-yl)-4-methyl-morpholine-2,5-diones.
Vukelić-Nikolić M, Kolarevć A, Tomović K, Yancheva D, Cherneva E, Najman S, Smelcerović A. Nat Prod Commun. 2015 Aug;10(8):1423-6.
Recently, we found that two cyclodidepsipeptides, 3,6-di-(propan-2-yl)-4-methyl-morpholine-2,5-dione (1) and 3-(2-methylpropyl)-6-(propan-2-yl)-4-methyl- morpholine-2,5-dione (2), are excellent inhibitors of xanthine oxidase. In order to obtain more information about the toxicological potential of compounds 1 and 2 on bone cells, the current study was designed to evaluate the effect of these compounds on viability and proliferation of MC3T3-E1 cells. Compound 1 showed neither cytotoxic nor stimulatory effect on cell viability, while compound 2 showed a slight stimulatory effect on cell viability. Both studied compounds showed slight stimulatory effects on proliferation of MC3T3-E1 cells, in a dose dependent manner. Additionally, an in silico toxicological study of compounds 1 and 2 was performed, and the results indicate that they have a good probability of safe biological intake.
3.Efficient delivery and distribution in skin of chlorogenic acid and resveratrol induced by microemulsion using sucrose laurate.
Yutani R1, Kikuchi T, Teraoka R, Kitagawa S. Chem Pharm Bull (Tokyo). 2014;62(3):274-80.
To achieve efficient skin delivery of polyphenols, we prepared a novel oil-in-water (o/w)-type microemulsion (MESL) using sucrose laurate as a surfactant and ethanol, isopropyl myristate and water as other components. We examined its usefulness by in vitro studies on skin delivery of chlorogenic acid and resveratrol as hydrophilic and hydrophobic polyphenols using Yucatan micropig skin, and also examined the difference in the distribution of these polyphenols in skin. MESL significantly improved skin incorporation of these polyphenols at all time points examined (6, 20, 40 h) in the epidermis and at 20 and 40 h in the dermis, compared with the microemulsion using Tween 80 as a surfactant component (MEK), although the solubilization capacity of MESL was lower than that of MEK. Using MESL, the incorporation amount in the dermis of each polyphenol increased with time, while the amount in the epidermis was almost constant during the time examined.
4.A novel sesquiterpene and three new phenolic compounds from the rhizomes of Acorus tatarinowii Schott.
Liang S1, Ying SS1, Wu HH2, Liu YT1, Dong PZ1, Zhu Y1, Xu YT3. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4214-8. doi: 10.1016/j.bmcl.2015.08.001. Epub 2015 Aug 6.
A novel sesquiterpene with an unprecedented epoxy lactone skeleton, named tatarinolactone, together with two new amides, a new biphenylpropanoid and two known lignans were isolated from the rhizomes of Acorus tatarinowii Schott. Their structures were identified as 6,7,8-trihydroxy-4α-isobutyl-4,7-dimethylhexahydro-6,8α-epoxychromen-2(3H)-one (1), (E)-methyl 4-[3-(4-hydroxy-3-methoxyphenyl)acrylamido]butanoate (2), (Z)-methyl 4-[3-(4-hydroxy-3-methoxyphenyl)acrylamido]butanoate enol isomer (3), (R)-4-hydroxy-3-[1-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propan-2-yl]-5-methoxybenzoic acid (4), (2S,3R)-ceplignan (5), and (2R,3S)-ceplignan (6), respectively, based on extensive spectroscopic analysis and by comparison to the known compounds. To test their effects on serotonin transporters, a high content assay using hSERT-HEK293 cell line was adopted. Results indicated that compounds 1 and 4 significantly inhibited SERT activity, while compounds 2, 3, 5, and 6 significantly enhanced SERT activity, which partly explain the traditional uses of the rhizomes of Acorus tatarinowii Schott in treatments of neuropsychiatric and digestive disorders.
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CAS 7780-06-5 propan-2-yl 3-phenylprop-2-enoate

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