Process R&D

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BOC Sciences begins with a thorough screening of the process parameters. Stress tests are also run to make sure that the reactions are controlled, for example, key impurities could be identified to determine if they have the potentiality to cause problems in the isolation of the final product. Efficiency of each operation is carefully evaluated to minimize the waste generation for the environmentally friendly synthesis. All the chemical operators in BOC Sciences undergo rigorous training and testing to ensure that safety procedures are both understood and followed.

BOC Sciences’chiral laboratories are well equipped for chiral resolution of compounds. Other services encompass chiral compounds synthesis and asymmetric catalysis synthesis. BOC Sciences offers the service of X-ray crystallography, a proven technique for determining the structure of compounds, especially the configuration of chiral compounds. We help our customers surmount obstacles in their research projects by conducting X-ray crystallography on crystal samples prepared by the client or synthesized and crystallized by us.

With support from our expert team of analysts, chemical engineers and QA professionals, BOC Sciences can develop scalable manufacturing processes efficiently to meet any need. We ensure that all the detailed data in every single step, such as time, temperature, purity and source of the starting material and solvent, purification method and storage condition is well recorded to make sure that all the steps are repeatable. BOC Sciences is expertized to provide safe, cost-effective process R&D as follows:

Evaluation and selection of routes for target molecules; Assessment of critical process parameters; Rapid screening of reactions conditions by utilizing parallel equipment; Perform reliable methods for in-process testing and analysis of intermediates and APIs; Development of continuous flow processes
Optimization of reaction conditions to have more efficiency operations by classical methods or statistical design of experiments; Process improvement for cost reduction and throughput maximization
Development of rapid scale-up of your cGMP raw materials or process intermediates from the kilogram to metric tonne scale both in the Kilo-Lab and Pilot Plant
Safety and impurity management strategy; Hazard and process safety evaluations with tools including multiple RC-1 reaction calorimeters, a HEL Thermal Screening unit (TSU) and multiple differential scanning calorimeters
Technology support
Low temperature, high temperature and high pressure chemistry; Photochemistry; Numerous LC/MS (including UFLC/MS and UPLC/MS with PDA and ELSD detectors); HPLC, GC/MS, GC and Headspace-GC; Bruker NMR; Waters autopurification systems; Thar SFC (Analytical and Preparative); FT-IR; UV-Vis; IR; KF titrator, polarimeter; X-ray crystallography

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