Prednisone - CAS 53-03-2

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Category
APIs
Product Name
Prednisone
Catalog Number
53-03-2
CAS Number
53-03-2
Molecular Weight
358.43
Molecular Formula
C21H26O5
Quality Standard
USP
COA
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MSDS
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Structure
CAS 53-03-2 Prednisone
Specification
Purity
>98%
Appearance
White or off-white crystalline powder
Reference Reading
1. Electrochemically modulated liquid chromatography: an electrochemical strategy for manipulating chromatographic retention
Jennifer A. Harnisch, Marc D. Porter*. Analyst, 2001, 126, 1841–1849
At the open circuit potential, the separation is only marginally effective. Prednisone and prednisolone are partially resolved, and cortisone and hydrocortisone virtually coelute. However, changes in Eapp result in marked differences in retention and, more interestingly, in elution order. This difference, which translates to a nonlinear dependence in plots of log kA vs. Eapp, is attribute in part to competition for adsorption sites on PGC by the supporting electrolyte. Specifically, as Eapp becomes more negative, the retention of both prednisone and prednisolone increases, but with prednisone increasing to a notably greater extent. This difference transposes the elution order of the two compounds at ~20.20 V. As such, prednisolone is retained more strongly than prednisone at the more positive extremes of Eapp, the two compounds coelute at 0.00 V, and prednisone is more strongly retained than prednisolone at more negative Eapp.
2. Development of three-component conjugates: to get nano-globes with porous surfaces, high in vivo anti-osteoporosis activity and minimal side effects
Guifeng Kang, Yuji Wang, Ming Zhao*, Shiqi Peng*. J. Mater. Chem., 2012, 22, 21740–21748
The described assessments herein were performed according to a protocol reviewed and approved by the ethics committee of CapitalMedical University. The committee assured that the welfare of the animals was in conformity with the requirements of the animal welfare act and according to the guide for care and use of laboratory animals. ICR mice (weighing 21.1±1.8 g, purchased from Animal Center of Peking University) were housed under temperature and humidity controlled conditions at a 12-hour light and 12-hour dark (6 p.m. to 6 a.m.) cycle for one day before being used. Each mouse in drug receiving groups was administered special food (containing 0.1% of calcium and 0.4% of phosphorus) and distilled water, while each mouse in blank control was administered normal food (containing 1.76% of calcium and 1.01% of phosphorus) and running water. Each mouse in the prednisone control group was injected with 6.3 mg kg-1 of prednisone intramuscularly twice a week and orally administered 0.2 mL of distilled water once a day. Each mouse in the treated group was injected with 6.3 mg kg-1 of prednisone intramuscularly twice a week and orally administered 110 nmol kg-1 of 4a–c in 0.2 mL of distilled water once a day. All mice were treated according to our protocol for 4 weeks. On the day after the last administration the mice were weighed, the blood was drawn from the eye orbit and then the mice were sacrificed with pentobarbital sodium (40.0 mg kg-1, i.p.) anesthesia. The mice were then immediately dissected to obtain the femur and organ.
3. Novel nano-materials, RGD-tetrapeptide-modified 17β-amino-11a-hydroxyandrost-1,4-diene-3-one: synthesis, self-assembly based nano-images and in vivo anti-osteoporosis evaluation
Yuji Wang, Jianhui Wu, Guifeng Kang, Ming Zhao*, Shiqi Peng*. J. Mater. Chem., 2012, 22, 4652–4659
Each of them in drug receiving groups was administered special food (containing 0.1% of calcium and 0.4% of phosphorus) and distilled water, while each of them in blank control was administered normal food (containing 1.76% of calcium and 1.01% of phosphorus) and running water. Each mouse in the prednisone control group was injected with 6.3 mg kg-1 of prednisone, intramuscularly, twice a week and orally administered 0.2 mL of distilled water once a day. Each mouse in the treated group was injected with 6.3 mg kg-1 of prednisone, intramuscularly, twice a week and orally administered 110 nmol kg-1of 5a–c in 0.2 of distilled water once a day. All mice were treated in the corresponding way for 4 weeks. On the next day of the last administration the mice were weighed, blood was drawn via an eye orbit, the mice were then sacrificed with pentobarbital sodium (40.0 mg kg-1, i.p.) anesthesia, and immediately dissected to obtain the femurs and organs.
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