Polyquaternium-32 - CAS 67504-24-9
Catalog number: 67504-24-9
Category: Main Product
Molecular Formula:
Molecular Weight:
Poly(acrylamide 2-methacryloxyethyltrimethyl ammonium chloride); Polyquaternium-32
1.Preventing sexual transmission of HIV: anti-HIV bioregulatory and homeostatic components of commercial sexual lubricants.
Nguyen D1, Lee H, Poast J, Cloyd MW, Baron S. J Biol Regul Homeost Agents. 2004 Jul-Dec;18(3-4):268-74.
Certain safe over-the-counter (OTC) sexual lubricants such as Astroglide, KY Liquid, Replens, Vagisil, ViAmor, and Wet Stuff inhibit both cell-free HIV and the production of HIV by infected leukocytes in vitro even in the presence of seminal fluid. To identify which components of the lubricants were active against HIV, we tested five components (glycerin, methylparaben, propylparaben, polyquaternium-32, and propylene glycol). The paraben preservatives and propylene glycol in the lubricants did not inhibit HIV, while the common natural homeostatic metabolite, glycerin, and the thickener polyquaternium-32 did strongly inactivate infectious HIV and HIV-infected leukocytes. Activity against HIV and HIV-infected cells by glycerin was stable through 24 hours at 37 degrees C. Glycerin and polyquaternium-32 were active at minimum concentrations of approximately 2% and 0.01%, respectively--well within the highest FDA safety guidelines. Both active components disrupted infected leukocytes within 5 minutes which resulted in inhibition of infectious HIV production by infected leukocytes of greater than 25 to 100-fold.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

Chemical Structure

CAS 67504-24-9 Polyquaternium-32

Quick Inquiry

Verification code

Featured Items