1.Characterization and Antihypertensive Effect of the Complex of ( )-β-pinene in β-cyclodextrin.
Moreira ÍJ, Menezes PP, Serafini MR, Araújo AA, Quintans-Júnior LJ, Bonjardim LR, Filho VJ, Júnior DB, Santos SL, Júnior WL, Scotti L, Scotti MT, Santos MR1. Curr Pharm Biotechnol. 2016 Apr 25. [Epub ahead of print]
This work aimed to characterize and evaluate the antihypertensive effect of the (-)-β-pinene/β-cyclodextrin (βP/β-CD) complex. The complex was prepared through physical mixture and slurry complexation methods and was analyzed through differential scanning calorimetry, thermogravimetry/derivative thermogravimetry, fourier transform infrared spectroscopy, diffraction X-ray, docking and scanning electron microscopy. Normotensive or L-NAME-induced hypertensive rats were used in pharmacological experiments. Mean arterial pressure (MAP) was determined with direct blood pressure measurements from the abdominal aorta. The drugs were orally administrated and their effects were recorded during 48 hours. Vascular effects of βP were evaluated in isolated ring of mesenteric artery. The physicochemical characterization showed βP/β-CD complex formation. In hypertensive rats (MAP = 156 ± 16 mmHg), the complex, but not βP alone, promoted hypotension at 36 and 48 hours after administration (MAP = 124 ± 3 and 110 ± 5 mmHg, respectively).
2.Pine Sawyers (Coleoptera: Cerambycidae) Attracted to α-Pinene, Monochamol, and Ipsenol in North America.
Miller DR1, Allison JD2, Crowe CM3, Dickinson DM4, Eglitis A5, Hofstetter RW6, Munson AS7, Poland TM8, Reid LS9, Steed BE10, Sweeney JD11. J Econ Entomol. 2016 Apr 22. pii: tow071. [Epub ahead of print]
Detection tools are needed for Monochamus species (Coleoptera: Cerambycidae) because they are known to introduce pine wilt disease by vectoring nematodes in Asia, Europe, and North America. In 2012-2014, we examined the effects of the semiochemicals monochamol and ipsenol on the flight responses of the sawyer beetles Monochamus carolinensis (Olivier), Monochamus clamator (LeConte), Monochamus mutator LeConte, Monochamus notatus (Drury), Monochamus obtusus Casey, Monochamus scutellatus (Say), and Monochamus titillator (F.) complex (Coleoptera: Cerambycidae) to traps baited with α-pinene. Experiments were set in pine forests in New Brunswick and Ontario (Canada), and Arizona, Georgia, Michigan, Montana, Oregon, South Carolina, Utah, and Washington (United States). In brief, 40 traps were placed in 10 blocks of 4 traps per block per location. Traps were baited with: 1) α-pinene; 2) α-pinene + monochamol; 3) α-pinene + ipsenol; and 4) α-pinene + monochamol + ipsenol.
3.Exploring divergent volatility properties from yield and thermodenuder measurements of secondary organic aerosol from α-pinene ozonolysis.
Saha PK, Grieshop AP. Environ Sci Technol. 2016 May 4. [Epub ahead of print]
There are large uncertainties in the parameters dictating the gas-particle partitioning of secondary organic aerosols (SOA), though this process has major influences on their atmospheric lifecycle. Here, we extract parameters that describe the partitioning of SOA from α-pinene ozonolysis using measurements from a dual-thermodenuder (TD) system that constrains both the equilibrium and kinetic properties that dictate SOA phase partitioning. Parallel TDs that vary temperature and residence time were used with an evaporation kinetics model to extract parameter values. An evaporation coefficient of order of 0.1 best describes the observed evaporation, suggesting equilibration time scales of atmospheric SOA on the order of minutes to hours. 20-40% of SOA mass consists of low volatility material (saturation concentration < 0.3 μg m-3) in the TD-derived SOA volatility distribution. While distinct from existing parameterizations from aerosol growth experiments, derived values are consistent with recent observations of slow room-temperature evaporation of SOA and contributions from extremely low volatility organic compounds formed during α-pinene ozonolysis.