Phenethyl cinnamate - CAS 103-53-7
Catalog number: 103-53-7
Category: Main Product
Molecular Formula:
C17H16O2
Molecular Weight:
252.31
COA:
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Purity:
98%
Appearance:
White crystals or amorphous powder
Synonyms:
B-PHENYLETHYL CINNAMATE; Benzylcarbinyl 3-phenyl propenoate; benzylcarbinyl cinnamate; BETA PHENYL ETHYL CINNAMATE; FEMA 2863; 2-Phenylethyl 3-phenyl propenoate; 2-phenylethyl cinnamate; PHENYLETHYL CINNAMATE
MSDS:
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Quantity:
Data not available, please inquire.
Boiling Point:
405.9ºC at 760mmHg
Melting Point:
54-56ºC
Density:
1.108g/cm3
1.Comment on 'Caffeic acid phenethyl ester lessens disease symptoms in an experimental autoimmune uveoretinitis mouse model' by Choi J.H. et al. [Exp. Eye Res. 134 (2015) 53-62].
Erdemli HK1, Akyol S2, Armutcu F3, Akyol O4. Exp Eye Res. 2015 Sep;138:124-5. doi: 10.1016/j.exer.2015.07.003. Epub 2015 Jul 10.
2.Caffeic acid phenethyl ester inhibits 3-MC-induced CYP1A1 expression through induction of hypoxia-inducible factor-1α.
Kim HG1, Han EH2, Im JH1, Lee EJ1, Jin SW1, Jeong HG3. Biochem Biophys Res Commun. 2015 Sep 25;465(3):562-8. doi: 10.1016/j.bbrc.2015.08.060. Epub 2015 Aug 18.
Caffeic acid phenethyl ester (CAPE), a natural component of propolis, is reported to have anticarcinogenic properties, although its precise chemopreventive mechanism remains unclear. In this study, we examined the effects of CAPE on 3-methylcholanthrene (3-MC)-induced CYP1A1 expression and activities. CAPE reduced the formation of the benzo[a]pyrene-DNA adduct. Moreover, CAPE inhibited 3-MC-induced CYP1A1 activity, mRNA expression, protein level, and promoter activity. CAPE treatment also decreased 3-MC-inducible xenobiotic-response element (XRE)-linked luciferase, aryl hydrocarbons receptor (AhR) transactivation and nuclear localization. CAPE induced hypoxia inducible factor-1α (HIF-1α) protein level and HIF-1α responsible element (HRE) transcriptional activity. CAPE-mediated HIF-1α reduced 3-MC-inducible CYP1A1 protein expression. Taken together, CAPE decreases 3-MC-mediated CYP1A1 expression, and this inhibitory response is associated with inhibition of AhR and HIF-1α induction.
3.Caffeic acid phenethyl ester protects lung alveolar epithelial cells from cigarette smoke-induced damage.
Barlas FB, Erdoğan S. Turk J Med Sci. 2015;45(3):534-41.
BACKGROUND/AIM: To evaluate the influence of caffeic acid phenethyl ester (CAPE) on cigarette smoke (CS)-induced cell damage, oxidative stress, and inflammation in human alveolar epithelial cells.
4.Sonoran propolis and some of its chemical constituents inhibit in vitro growth of Giardia lamblia trophozoites.
Alday-Provencio S1, Diaz G2, Rascon L1, Quintero J1, Alday E1, Robles-Zepeda R1, Garibay-Escobar A1, Astiazaran H3, Hernandez J4, Velazquez C1. Planta Med. 2015 Jun;81(9):742-7. doi: 10.1055/s-0035-1545982. Epub 2015 May 22.
Propolis is a cereus resin with a complex chemical composition that possesses a wide range of biological activities. The aim of this study was to evaluate the in vitro anti-Giardia lamblia activity of Sonoran propolis collected from three different areas of Sonoran Desert in northwestern Mexico (Caborca, Pueblo de Alamos, and Ures) and some of its chemical constituents. Additionally, we also analyzed the seasonal effect on the anti-G. lamblia activity of propolis. G. lamblia trophozoite cultures were treated with different concentrations of Sonoran propolis or chemical compounds during 48 h cell proliferation and cell viability were determined. Ures propolis showed the highest inhibitory activity against G. lamblia (IC50 63.8 ± 7.1 µg/mL) in a dose-dependent manner (Ures > Pueblo de Alamos > Caborca). Season had a significant effect on the in vitro anti-G. lamblia activity of Ures propolis. Summer propolis showed the highest inhibitory effect on the G.
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CAS 103-53-7 Phenethyl cinnamate

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